Гаджева В. Синтез, свойства и биологична активност на спин-белязани и небелязани нитрозоуреи и триазени. Дисертация за присъждане на научна степен “Доктор”, 1991 Гаджева В


II.Участия в международни и български форуми (Абстракти)



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II.Участия в международни и български форуми (Абстракти)

II.1. Абстракти, публикувани в международни списания или сборници от международни научни форуми:



1988

  1. Gadjeva V., A. Geleva, Z. Raikov, B. Tchemishev: Derives spin-marques de nitrosoureas, X Session des Journees Medicales Balkaniques, 25-28 Juin.1987, Cluj-Napoca, Roumanie, Suppl. to Archives de L’Union Medicale Balkanique, 26(1-4), 111, 1988

  2. Geleva A., V. Gadjeva, Z. Raikov, B. Tchemishev: Formation des radicaux libres de Belustine (CCNU) et BICNU (BCNU). X Session des Journees Medicales Balkaniques, 25-28 Juin.1987, Cluj-Napoca, Roumanie, Suppl. to Archives de L’Union Medicale Balkanique, 26(1-4), 112, 1988.

  3. Gadjeva V, Е. Raikova, Z. Raikov, M. Stefanova, Ts. Ivanova: Determination of the carbamoilating activity of new antitumour nitrosoureas by the ESR method. 14-th International congress of biochemistry, July 10-15, 1988, Prague, Czechoslovakia


1989

  1. Raikov Z., М. Koch, V. Gadjeva and G. Kolar: Spin-labeled triazenes with a potential tumor inhibitory activity. Fifth SEK Symposium of the German Cancer Society, April 10-12, Heidelberg, Germany, Suppl. to J. Cancer Res. Clin. Oncol.,115, p.S62, TH 35, 1989. (IF= 2,503)

  2. Gadgeva V., Z. Raikov, E. Raikova, M. Ilarionova, D. Todorov: Synthesis and study of spin-labeled nitrosourea. International Conference on Nitroxide Radicals. September 18-23, 1989, Novosibirsk, USSR

  3. Kolar G, Z. Raikov, V. Gadgeva, M. Ilarionova, D. Todorov: Synthesis and study of spin-labeled triazenes. International Conference on Nitroxide Radicals. September 18-23, 1989, Novosibirsk, USSR


1990

  1. Todorov D., M. Ilarionova, Z. Raikov, R. Gugova, G. Demirov, A. Geleva A, V. Gadgeva, S. Varbanov: Antitumour activity of several groups novel nitrosoureas. 15th International Cancer Congress, August, 16-22, Hamburg, Suppl. to J. Cancer Res. Clin. Oncol., 116, p.469, A4.124.10, 1990. (IF= 2,503)

1991

  1. Gadjeva V., E. Raikova, Z. Raikov and T. Vlaikova: Synthesis and study of tyrosine nitrosoureas as potencial anticancer agents, XI Biennial Meeting of the EACR, November 3-6, Genoa, Italy, Suppl.3 to European J Cancer, 27, pS52, 1991. (IF= 3,706)

  2. Raikov Z., V. Gadjeva, and T. Vlaikova: Increase of DOPA-oxydase activity of mushroom tyrosinase by spin-labeled triazenes. XI Biennial Meeting of the EACR, November 3-6, Genoa, Italy, Suppl. 3 to European J Cancer, 27, pS55, 1991. (IF= 3,706)

  3. Gadjeva V, Z. Raikov: SLCNCH. Drug Data Report 13(4),344, 1991.


1992


  1. Gadzheva V., Z. Raikov, E. Raikova, T. Vlaikova, M. Ilarionova, D. Todorov: Synthesis and study of new nitrosoureas containing polimer carrier of the chloroethyl group. 7-th NCI-EORTC Symposium on New Drugs in Cancer Therapy, March 17-20, 1992, Amsterdam

  2. Raikova E., V. Gadzheva, Z. Raikov, T. Vlaikova: Comparative Investigation of the modulating effect of new nitrosoureas on the DOPA-oxidase activity of tyrosinase. 7-th NCI-EORTC Symposium on New Drugs in Cancer Therapy, March 17-20, 1992, Amsterdam.

  3. Ilarionova M., D. Todorov, Z. Raikov, V. Gadjeva, A. Zheleva: Third generation "Desease oriented" novel antimelanomic nitrosoureas. 7-th NCI-EORTC Symposium on New Drugs in Cancer Therapy, March 17-20, 1992, Amsterdam.



1994

  1. Gadzheva V, Raikov Z, Ichimory K, Nakazawa H: Antioxidant action of newly synthesized spin-labeled antitumour agents with nitrosourea and triazene moiety. 8-th NCI-EORTC symposium on new drugs in cancer therapy, March 15-18, 1994, Amsterdam

  2. Gadzheva V, Z. Raikov, E. Raikova, H. Nakazawa, T. Matsuyama, D. Habu: Newly synthesized tyrosine containing nitrosoureas with selective cytotoxicity. 8-th NCI-EORTC symposium on new drugs in cancer therapy, March 15-18, 1994, Amsterdam.


1996


  1. Gadzheva V, A Zheleva, T Matsuyama MD, S Habu MD. Investigation the effect of newly synthesized DNA-alkylating antitumor agents spin-labeled nitrosoureas on the cytotoxicity of l-cyclohexyl-3-chloroethyl-3-nitrosourea (CCNU) Cancer Detection and Prevention 1996; 20(5). (IF = 1.180)


1997


  1. Ivanov IT. and Gadzheva VG, Influence of DNA Alkylating agents – Nitrogen mustards and triazenes on the therminal stability of proteins erythrocyte membrane. 11 th Balkan Biochemical Biophysical days, 452, May 15-17, Thessaloniki, Greece, 1997



2000

  1. Hristakieva E., V. Gadjeva, S. Popova and T. Vlajkova, "Influence of helio - and thalassotherapy on the superoxide dismutase activity in psoriatic and vitiligo patients" Тhe 21 International congress of Thalassotherapy in Hammamet-Tunisia; 30 January 2 February 2000.

  2. Gadjeva V, V.Ivanova, S. Popova and K.Yankov: Erythrocyte superoxide dismutase activity and lipid peroxidation in patients with hematological diseases. European Association for Cancer Research - 2000; Halkidiki-Hellas, 30. May – 3. June 2000.


2001

  1. Gadjeva V, E. Hristakieva ,S. Karamihov. Correlation between blood antioxidant levels and lipid peroxidation in patients with eruptive psoriasis. J.Eur Academy of Dermatol and Venerology, (2001), v15, suppl. 2, P17-9. (IF 0,981)

  2. Hristakieva E, V. Gadjeva,. Oxidative stress in patients with vitiligo. J.Eur Academy of Dermatol and Venerology, (2001), v15, suppl. 2, P23-19. (IF 0,981)



2003

  1. Zheleva A., M. Zhelev, V. Gadjeva D. Michelot. Proprietes prooxydantes de la phalloidine et action hepatotoxique 11 emes Rencontres en toxinologie Sfet, “Toxinogenese naturelle toxinogenese anthropique”, Paris, 11 et 12 decembre, 2003.

  2. Hristakieva E, V. Gadjeva. Oxygen metabolism of granulocytes in patients with vitiligo. J.Eur Academy of Dermatol and Venerology JEADV (2003) 17 (Suppl.3),1; p 359. (IF- 0,981)


2004

  1. Hristakieva E., V. Gadjeva. Influence of the climate Factors on the antioxidant status in psoriasis and vitiligo patients. EADV II. Spring Symposium, Budapest, Hungary, 2004, Abstr.book p.173.

2008

  1. Zhelev Zh., Matsumoto K., Gadjeva V., Zheleva A., Bakalova R., Aoki I., Anzai K. EPR signal Dynamic of Several Nitroxyl-Labeled Anticancer Drugs in Blood In vitro and In vivo. 5th International Conference on Nitroxide Radicals, Ancona, Italy, 7-11th September, 2008, Abstr. book p.22.

  2. Zhelev Zh., Bakalova R., Matsumoto K., Gadjeva V., Aoki I., Anzai K, Kanno I. Nitroxyl Labels in Brain Imaging Using T1-Weighted MRI. 5th International Conference on Nitroxide Radicals, Ancona, Italy, 7-11th September, 2008, Abstr.book p.59.

  3. Zhelev Z., R. Bakalova, I. Aoki, K. Yoneyama, T. Obata, V. Gadjeva, and I. Kanno. – Nanohybrids for multimodal molecular imaging: synthesis, spectral characteristics and application, E-MRS 2008 Spring Meeting, May 26-30, 2008, Strasbourg, France.

  4. Bakalova R., Z. Zhelev, I. Aoki, K. Matsumoto, V. Gadjeva, and I. Kanno. – Multimodal molecular probes: chemical design, spectral characteristics and application for in vitro and in vivo imaging, Annual Conference of the Japanese Society for Molecular Imaging, May 22-23, 2008, Fukui, Japan p. 80 (P1-10).

  5. Zhelev Z., R. Bakalova, I. Aoki, M. Mileva, V. Gadjeva, and I. Kanno. – Sensitization of cancer cells to radiation using hybrid nanoparticles: Activation of apoptotic factors, 5th International Conference on Nanosciences & Nanotechnologies NN08, July 12-15, 2008, Thessaloniki, Greece, p. 168.

  6. Zhelev Z., I. Aoki, R. Bakalova, V. Gadjeva, and I. Kanno. – Multomodal quantum dots: Direct intracellular delivery, photosensitization, and cytotoxic effects, 5th International Conference on Nanosciences & Nanotechnologies NN08, July 12-15, 2008, Thessaloniki, Greece, p. 169.

  7. R. Bakalova, Zhelev Z., I. Aoki, K. Matsumoto, V. Gadjeva, and I. Kanno. – Nanobioprobes for multimodal molecular imaging: Chemical design, spectral characteristics, and biomedical applications, 5th International Conference on Nanosciences & Nanotechnologies NN08, July 12-15, 2008, Thessaloniki, Greece, p. 52.

  8. Zhelev Z., R. Bakalova, I. Aoki, V. Gadjeva, I. Kanno. – Quantum dots in multimodal imaging: Probe design, spectral characteristics and application, Would Molecular Imaging Congress, September 10-13, 2008, Nice, France.




  1. Zhelev, Zh., Ken-Ichiro Matsumoto, V. Gadjeva, A. Zheleva, R. Bakalova, I. Aoki, K. Anzai. EPR signal dynamic of several nitroxyl-labeled anticancer drugs in blood in vitro and in vivo.5th International Conference on Nitroxide radicals SPIN 2008, Ancona, Italy, 7-11 September 2008, Book of Abstracts, P22.


2009

  1. Zheleva, A., R. Kumar, R. Sharma, Y. Karamalakova, V. Gadjeva. DPPH Radical scavenging capacity of grude extracts and their fractions isolated from bacterium Bacillus sp. 11th International Workshop Electron Magnetic Resonance of Disordered systems, June 11-18, 2009 Sofia-Boyana, Bulgaria, Book of Abstracts, p39.

  2. Gadjeva, V., R. Kumar, R. Sharma, Y. Karamalakova, A. Zheleva. EPR spectra in powder and solution forms of crude extracts and fractions isolated from bacterium Bacillus sp. 11th International Workshop Electron Magnetic Resonance of Disordered systems, June 11-18, 2009 Sofia-Boyana, Bulgaria, Book of Abstracts, p25.

  3. Zhelev, Z., R. Bakalova, Ken-Ichiro Matsumoto, I. Aoki, V. Gadjeva, A. Zheleva, K. Anzai, I. Kanno. Real-time Magnetic Resonance Imaging of Blood Brian Barrier Permeability of Conventional Therapeutics Using Nitroxides as Spin-labels. 4th European Molecular Imaging Meeting – Barcelona, 27-30 May, 2009. Book of Abstracts.

  4. Zheleva A., R. Kumar, R. Sharma, Y. Karamalakova, V. Gadjeva. DPPH Radical scavenging capacity of grude extracts and their fractions isolated from bactirium Bacillus SP. International Conference on EPR, Sofia, 2009

  5. Kumar R., V. Gadjeva, R. Sharma, Y. Karamalakova, A. Zheleva. EPR spectra in powder and solution forms of crude extracts and fractions isolated from bacterium Bacillus sp. International Conference on EPR, Sofia, 2009.

  6. Zhelev Z., Bakalova R., Matsumoto K., Aoki I., Gadjeva V., Anzai K., Kanno I. – Nitroxide radicals in brain imaging using T1 weighted MRI, JSMI, May 2009, Vol. 2, No. 2, p. 114

  7. Zhelev Z., Bakalova R., Matsumoto K., Aoki I., Gadjeva V., Zheleva A., Anzai K., Kanno I. – Real-time MRI of blood-brain barrier permeability of conventional therapeutics using nitroxides as spin-labels, 4th European Molecular Imaging Meeting, Barcelona, Spain, May 27-30, 2009-11-24


2010

  1. Yanka Karamalakova, Galina Nikolova, Tsvetelin Georgiev, Petia Hadjibojeva, Anna Tolekova, Veselina Gadjeva, Antoaneta Zheleva. Generation of lipid radicals in mice liver tissue after tratment by spin labelled and non labelled nitrosoureas –an ex vivo EPR spectroscopy study. 2nd International Student Medical Congress Koshice June 21-24, 2010-09-10.Folia Medica Cassoviensia, Tomus 65, № 1, p. 195-196, Suppl. 1,2010

  2. Yanka Karamalakova, Galina Nikolova, Antoaneta Zheleva, Vesselina Gadjeva, Raj Kumar, Krishna Chuttani, Anil K. Mishra, Rakesh K. Sharma, A.Tolekova. A new promising hepatoprotector AQGPD with natural origin. 21st European Students’ Conference, Berlin, Germany, 2010-09-13.European Journal of Medical Research, Volume 15,Suppl. 1, (IF-1.130).

  3. Karamalakova, Y., V. Gadjeva, A. Zheleva. Generation of lipid radicals in mice liver tissue after treatment by spin labeled and non labeled nitrosoureas – an ex vivo EPR spectroscopy study. Folia Medica Cassoviensia, vol. 65 (1), p. 195-196, Suppl. 1, 2010, Abstract ID: 222.

  4. Dhaker, A.S., M. Adhikari, J. Sharma, P. Malhotra, A. Zheleva, Y. Karamalakova, V. Gadjeva, R. Chawla, D. Gupta, R. Kumar, R. K. Sharma, S. Sultana, R. Arora. EPR Spectroscopy Confirms Modification of Oxidative stress by Psoralea corylifolia lin, as the Mechanism of Radioprotection. Journal of Advanced Biotechnology, Vol. 10 (5): p 29, 2010.

  5. Karamalakova, Y., J. Sharma, A. Zheleva, R. Arora, V. Gadjeva. Comparative Evalution on Antioxidant Properties of Bulgarian and Indian Essential Oils by two Different Methods. Journal of Advanced Biotechnology, Vol. 10 (5): p 24, 2010.

  6. Karamalakova, Y., Zheleva, A., Nikolova, G., Kumar, R., Chuttani, K., Mishra, A.K., Sharma, R.K., Gadjeva, V. A new promising hepatoprotector AQGPD with natural origin. Eur. J. Med. Res.,vol. 15/ suppl I, 181-182, 2010. (IF=1.130)

  7. Zhelev, Z., R. Bakalova, I. Aoki, V. Gadjeva, and I. Kanno. – Diagnostic potential of nitroxide radicals in cancer using MRI tomography, Annual Conference of the Japanese Society for Molecular Imaging, May 21-23, 2010, Kyoto, Japan, JSMI Report ‘2010, p. 89.

  8. Zhelev, Z., R. Bakalova, I. Aoki, V. Gadjeva, and I. Kanno. – Magnetic resonance imaging of cancer based on tissue redox activity, World Molecular Imaging Conference, September 8-12, 2010, Kyoto, Japan.

  9. Yanka Karamalakova, Jyoti Sharma, Antoaneta Zheleva, Rajesh Arora, Rakesh K. Sharma, Veselina Gadjeva. Comparative evalation on antioxidant properties of Bulgarian and Indian essential oils by two diferent methods. International Conference on Radiation Biology, Chennai, India, 2010-11-24.


2011


  1. Veselina Gadjeva, Anna Tolekova, I.Ionkova,  Yanka Karamalakova, Galina Nikolova, Antoaneta Zheleva. Evaluation the levels of oxidative stress in liver and kidneys of mice after single treatment by naturally isolated astragaloside and formerly synthesized spin labelled nitrosourea SLENU- a comperative EPR ex vivo spectroscopy study. III Internatinal conference of oxidative stress. Havana-Redox. 2011, Cuba,2011-27-29.01, Revista Cubana de Farmacia, Vol.45 supl.1, AB., p-1-139.

  2. Antoaneta Zheleva, Anna Tolekova, Yanka Karamalakova, Galina Nikolova, Veselina Gadjeva. Ex vivo Evaluation of oxidative stress caused by 2-chlorethylynitrosourea antitumor agent in mice liver tissue- a comperative study by two different methods. III Internatinal conference of oxidative stress. Havana-Redox. 2011, Cuba, 2011-27-29.01, Revista Cubana de Farmacia, Vol.45 supl.1, AB., p-1-139.

  3. Karamalakova, Y., K. Chuttani, V. Gadjeva, A.K. Mishra, A. Zheleva. ROS production, Radiolabelling, biodistribution and gamma scintigraphy in healthy and tumor bearing mice after single treatment by two different 2-chloroethylnitrosoureas. III rd Medical Students’ Research Congress, Istambul, Turkey, 2011-05-06. AB, 110-111.

  4. Ivanov, V., Y. Karamalakova, V. Gadjeva, A. Zheleva. Radical scavenging activity of limonene citrus oil before and after UV radiation – an Electron Paramagnetic Resonance spectroscopy study. III rd Medical Students’ Research Congress, Istambul, Turkey, 2011-05-06. AB, 109-110.

  5. Georgieva, E., Y. Karamalakova, G. Nikolova, V. Gadjeva, D. Pavlov, A. Zheleva. DPPH scavenging capacity of seeds and leaves ethanol extracts of ‘’Cynara scolymus L.’’ – a comparative study by two different methods. III rd Medical Students’ Research Congress, Istambul, Turkey, 2011-05-06. AB, 101-102.

  6. Yanka Karamalakova, Krishna Chuttani, Vesselina Gadjeva, Anil K. Mishra, Antoaneta Zheleva. ROS production, Radiolabelling, biodistribution and gamma scintigraphy in healthy and tumor bearing mice after single treatment by two different 2-chloroethylnitrosoureas. III rd Medical Students’ Research Congress, Istambul, Turkey, 2011-05-06. AB, 110-111.

  7. Zheleva, A., Y. Karamalakova, A. Mishra, V. Gadjeva. Studies on biological activity of a potential alkylating antitumour drug containing nitroxyl free radical structure. 6th SPIN Conference, 26-29 September, 2011, Marseille, France, Book of Abstracts, p 129.

  8. Gadjeva, V., Karamalakova, Y., Mishra, A., Zheleva, A. Biological activity of a formerly synthesized nitroxyl free radical containing antioxidant. 6th SPIN Conference, 26-29 September, 2011, Marseille, France, Book of Abstracts, p 128.


2012

  1. G.Nikolova, V. Mancheva, Y. Karamalakova, B. Grigorov, I.Manchev, A. Zheleva, V. Gadjeva. Oxidative stress parameters in patients with Parkinson disease., Prague, CZ, Book of Abstracts, 24th European Congress of Pathology, 8 - 12 September 2012, Prague, CZ, Book of Abstracts.

2013


  1. G. Nikolova, B. Grigorov, Y.Karamalakova, A.Zheleva, V. Gadjeva, “Effect of the therapy with Madopar on the free radical formation of patients with Parkinson disease: an EPR study”, 24th European Students’ Conference, Berlin, Germany, 2013-09-04. poster session, Abstract book, pp:26

  2. Adhikari M., Ivanov V., Dhaker A., Singh K., Baboota S., Gadjeva V., Karamalakova Y., Khar RK., Chawla R., Arora R., Sharma RK Development, Characterization and Evaluation of Silymarin Nanoemulsion as Radioprotector, 27 May, 2013, Novij Svet, AP Krim,Ukraina

2015


  1. Vanya Ilieva-Fartunova, Vanya Tsoneva, Galina Nikolova, Antoaneta Zheleva, Atanas Koychev, Veselina Gadjeva. Association of free radical formation, severity of disease and degree of systemic inflammation in patients with bronchial asthma ERS International Congress 2015; 25th International Congress, Amsterdam, Netherlands 26 –30 September 2015, Abstracts in European Respiratory Journal VOL 4 6 / SU P P L E M E N T 5 9 / S E P T E M B E R 2 0 1 5, PA3916

  2. Vania Ilieva, Vania Coneva, Galina Nikolova, Antoaneta Zheleva, Yanica jeliazkova. Correlation between end products of oxidation of lipids and proteins with systemic inflammation in patients with bronchial asthma.Folia Medica 2015; 57; Suppl.1.


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