Курс лекции „Обмяна на веществата (Метаболитни процеси)”
Организатори: ИМИ-БАН и Биомат Форум; лектор: Светослав Марков
Лекция 1 ИМИ, зала 164, 26.11.2015, 16 – 17 ч.
Съдържание
А. Мотивация: управление на обмяната на веществата
Б. Основни понятия
Метаболизъм (в клетка) >10^13
https://bg.wikipedia.org/wiki/Клетка
https://bg.wikipedia.org/wiki/Метаболизъм
https://bg.wikipedia.org/wiki/Метаболитен_път
Ензими и белтъци, аминокиселини
https://bg.wikipedia.org/wiki/Ензим
https://bg.wikipedia.org/wiki/Белтък
https://bg.wikipedia.org/wiki/Аминокиселина
https://en.wikipedia.org/wiki/Essential_amino_acid
Каршиков, А., Белтъчна структура - анимация MPG
Нуклеотиди, ДНК, РНК
https://bg.wikipedia.org/wiki/Нуклеотид
https://bg.wikipedia.org/wiki/Дезоксирибонуклеинова_киселина
https://bg.wikipedia.org/wiki/Рибонуклеинова_киселина
Рибозоми
https://bg.wikipedia.org/wiki/Рибозома
Метаболитни пътеки и мрежи
https://bg.wikipedia.org/wiki/Метаболитен_път
Лекция 2 ИМИ, зала 164, 21.01.2016, 15 – 16:30 ч.
Съдържание
В. Генна експресия Централна догма в молекулярната биология
Преговор
https://bg.wikipedia.org/wiki/Клетка
https://bg.wikipedia.org/wiki/Генна_експресия
https://bg.wikipedia.org/wiki/Централна_догма_в_молекулярната_биология
Видове белтъци според техните функции
https://bg.wikipedia.org/wiki/Ензим
https://bg.wikipedia.org/wiki/Рецептор
https://bg.wikipedia.org/wiki/Йонен_канал
https://bg.wikipedia.org/wiki/Хормон
Белтъчни структури (органели)
https://bg.wikipedia.org/wiki/Калиево-натриева_помпа
https://bg.wikipedia.org/wiki/Антитяло
https://bg.wikipedia.org/wiki/Рибозома
https://bg.wikipedia.org/wiki/Лизозома
https://bg.wikipedia.org/wiki/хранене
Известни режими на хранене и диети
http://www.hisarlaka.com/dieti/1586-dietata-na-petya-raeva.html
Кleta4no hranene
https://www.zdravoslovno.com/blog/barbara-wren
http://e-zdrave.eu/index.php?route=product/category&path=53_54
http://www.alloe.net/publikacii/kleta4no%20hranene.pdf
Gabriel method
http://www.thegabrielmethod.com/
http://www.dietsinreview.com/diets/the-gabriel-method/
Paleo Diet
https://en.wikipedia.org/wiki/Paleolithic_diet
English version
Lecture course “Metabolic processes”
Contents
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Motivation: Management of metabolic processes and diseases– some examples
Metabolic management of brain cancer
http://www.sciencedirect.com/science/article/pii/S0005272810006857
Metabolic Processes of osteoarthritis
http://www.limbrel.com/hcp-metabolic-processes.php
http://www.genome.jp/kegg/
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Preliminaries: Basic knowledge
Metabolism (in the cell) >10^13 cells in humans
https://en.wikipedia.org/wiki/Cell_(biology)
https://en.wikipedia.org/wiki/Eukaryote
https://en.wikipedia.org/wiki/Metabolism
https://en.wikipedia.org/wiki/Metabolic_pathway
http://www.metabolicvisualizer.org/
http://www.wikipathways.org/index.php/WikiPathways
Enzymes & proteins
https://en.wikipedia.org/wiki/Enzyme
https://en.wikipedia.org/wiki/Enzyme#Metabolism
https://en.wikipedia.org/wiki/Protein
https://en.wikipedia.org/wiki/Amino_acid
http://highered.mheducation.com/sites/0072943696/student_view0/chapter2/animation__protein_denaturation.html
https://www.youtube.com/watch?v=qBRFIMcxZNM
http://www.bcconline.com/biol10rs/Pearson-Animations/protein_structure.swf
https://en.wikipedia.org/wiki/Essential_amino_acid
Karshikoff, A., Protein structucture animation MPG
Nucleotides
https://en.wikipedia.org/wiki/Nucleotide
https://en.wikipedia.org/wiki/Transcription_%28genetics%29
https://en.wikipedia.org/wiki/Messenger_RNA
https://en.wikipedia.org/wiki/Translation_%28biology%29
Signalling pathways
https://www.google.bg/?gfe_rd=cr&ei=sv1SVoe9BbCz8weotaLACA&gws_rd=ssl#q=signalling+pathways+ppt
https://www.google.bg/?gfe_rd=cr&ei=sv1SVoe9BbCz8weotaLACA&gws_rd=ssl#q=signalling+pathways+ppt
Gene expression
https://en.wikipedia.org/wiki/Gene_expression
Ribosomes
https://en.wikipedia.org/wiki/Ribosome
https://www.dnalc.org/view/16933-3D-Animation-of-DNA-to-RNA-to-Protein.html
https://www.dnalc.org/view/15501-Translation-RNA-to-protein-3D-animation-with-basic-narration.html
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Biomathematics perspective
Enzyme kinetics
https://en.wikipedia.org/wiki/Enzyme_kinetics
The law of mass action
https://en.wikipedia.org/wiki/Law_of_mass_action
Cato M. Guldberg and Peter Waage between 1864 and 1879 in
The law of Victor Henri
https://en.wikipedia.org/wiki/Victor_Henri
http://www.biomath.bg/s%20markov%20publications/A2014-BMC-Stanko-Gergana.pdf
http://www.biomath.bg/s%20markov%20publications/A20015-MATCOM-Stanko-michaelis.pdf
Bacterial growth
http://www.biomath.bg/s%20markov%20publications/A2015-MathChem_Hausdorff_Dist.pdf
http://www.biomath.bg/s%20markov%20publications/A2013-Biomath-cell-growth.pdf
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Management of metabolic processes
Some examples of diseases
https://en.wikipedia.org/wiki/Proteopathy
protein misfolding and disease; the role of chaperones
https://en.wikipedia.org/wiki/Post-translational_modification
Metabolic management of brain cancer
http://www.sciencedirect.com/science/article/pii/S0005272810006857
Metabolic Processes of osteoarthritis
http://www.limbrel.com/hcp-metabolic-processes.php
The microvascular system:
https://en.wikipedia.org/wiki/Capillary
http://cshperspectives.cshlp.org/content/early/2014/10/23/cshperspect.a016345
http://ndt.oxfordjournals.org/content/early/2010/10/08/ndt.gfq635.full
Diabetis
http://www.eufic.org/article/en/diet-related-diseases/obesity/expid/basics-obesity-overweight/
https://cspinet.org/new/pdf/cdc_briefing_book_fy10.pdf
https://en.wikipedia.org/wiki/Metabolic_acidosis
Thyroid diseases
https://en.wikipedia.org/wiki/Thyroid_disease
Glaucoma
https://en.wikipedia.org/wiki/Glaucoma
Management of metabolic processes – some analogues
A state. A home (kitchen). Potato pilling. Robots in war.
Nutrition
https://en.wikipedia.org/wiki/Nutrition
Management of metabolic processes – some known regimes and diets discussed
Familiar nutritional and dieting regimes
Separate nutrition
http://dietsindetails.com/article_separated_nutrition.html
http://joyoflosingweight.com/nutrition/47-separate-nutrition.html
Separate nutrition: optimization of the work of body systems? Article in Russian
Konyshev VA, Vasilevskaia LS
http://www.ncbi.nlm.nih.gov/pubmed/1514251
Fasting
https://en.wikipedia.org/wiki/Fasting
http://jeune-et-randonnee.pagesperso-orange.fr/devries.pdf
http://www.ncbi.nlm.nih.gov/pubmed/24434759
http://news.nationalpost.com/health/therapeutic-fasting-741073
http://nutritionstudies.org/fasting-effective-ancient-therapy-todays-health-concerns/
one day fasting (in joga)
The diet of Petya Raeva
http://www.hisarlaka.com/dieti/1586-dietata-na-petya-raeva.html
Cell nutrition
https://www.zdravoslovno.com/blog/barbara-wren
http://e-zdrave.eu/index.php?route=product/category&path=53_54
http://www.alloe.net/publikacii/kleta4no%20hranene.pdf
Gabriel method
http://www.thegabrielmethod.com/
http://www.dietsinreview.com/diets/the-gabriel-method/
Paleo Diet
https://en.wikipedia.org/wiki/Paleolithic_diet
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Personal experience and results
http://www.biomath.bg/S_Markov.php#Publications
http://www.biomath.bg/s%20markov%20publications/A2013-Biomath-cell-growth.pdf
http://www.biomath.bg/s%20markov%20publications/A20015-MATCOM-Stanko-michaelis.pdf
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People, books, history
Victor Henri
J. Murray
R. Tsanev
7. Proteopathy
https://en.wikipedia.org/wiki/Proteopathy
CHRISTOPHER M. DOBSON, Protein misfolding, evolution and disease, TIBS 24, 1999
Reynaud, E. (2010) Protein Misfolding and Degenerative Diseases. Nature Education 3(9):28
http://www.nature.com/scitable/topicpage/protein-misfolding-and-degenerative-diseases-14434929
Anfinsen, C. B. The formation and stabilization of protein structure. Biochemical Journal 128, 737–749 (1972)
Beadle, G. W. & Tatum, E. L. Genetic control of biochemical reactions in Neurospora. PNAS 27, 499–506 (1941)
Chiti, F. & Dobson, C. M. Protein misfolding, functional amyloid, and human disease. Annual Review of Biochemistry 75, 333–366 (2006)
Dill, K. A. & Chan, H. S. From Levinthal to pathways to funnels. Nature Structural Biology 4, 10–19 (1997)
Dobson, C. M. Protein folding and misfolding. Nature 426, 884–890 (2003) doi:10.1038/nature02261
Dobson, C. M. Protein misfolding diseases: Getting out of shape. Nature 418, 729–730 (2002) doi:10.1038/418729a
Ellis, J. Proteins as molecular chaperones. Nature 328, 378–379 (1987) doi:10.1038/328378a0
Fändrich, M. & Dobson, C. M. The behaviour of polyamino acids reveals an inverse side chain effect in amyloid structure formation The EMBO Journal 21, 5682-5690 (2002).
Finkel, T. Radical medicine: Treating ageing to cure disease. Nature Reviews Molecular Cell Biology 6, 971–976 (2005)
Gamow, G. & Ycas, M. Statistical correlation of protein and ribonucleic acid composition. PNAS 41, 1011–1019 (1955)
Kaufman, R. J., et al. The unfolded protein response in nutrient sensing and differation. Nature Reviews Molecular Cell Biology 3, 411-421 (2002)
Laskey, R. A. et al. Nucleosomes are assembled by an acidic protein which binds histones and transfers them to DNA. Nature 275, 416–420 (1978) doi:10.1038/275416a0
Levinthal, C. Are there pathways for protein folding? Journal de Chimie Physique et de Physico-Chimie Biologique 65, 44–45 (1968)
Lin, M. Y. & Beal, M. F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787–795 (2006)
V. Markov
Ivan Mitov, 130th anniversary of Prof. Dr. Vladimir Markov, Biomath 2 (2013), 1312312,
http://dx.doi.org/10.11145/j.biomath.2013.12.312
https://www.google.bg/?gfe_rd=cr&ei=sv1SVoe9BbCz8weotaLACA&gws_rd=ssl#q=nestor+markov&start=10
N. Markov
http://www.sustz.com/Proceeding09/Papers/Social%20studies/History/N_KANEV.pdf
https://bg.wikipedia.org/wiki/%D0%9D%D0%B5%D1%81%D1%82%D0%BE%D1%80_%D0%9C%D0%B0%D1%80%D0%BA%D0%BE%D0%B2
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