Секция: “Микробен биосинтез и биотехнология”
Ръководител секция:
Ст.н.с. I ст. Младенка Паунова Илиева-Стоилова, д.т.н.
e-mail: mladenka.stoilova@gmail.com; lbpmbas@yahoo.com;
tel.: +359 32 / 642 430
CV
научни трудове
Списъчен състав:
Ст. н . с. II ст. д-р Бонка Иванова Цветкова
e-mail: bonka_ivanova@abv.bg
служебен тел. +359 2 / 979 31 65
Ст. н . с. II ст. д-р Александър Борисов Рътков
e-mail:
служебен тел. +359 2 / 979 31 80/79
Ст. н . с. II ст. д-р Пенка Първанова Алексиева
e-mail: aleks57@abv.bg
служебен тел. +359 2 / 979 31 45/12
Ст. н . с. II ст. д-р Венета Боянова Иванова
e-mail: venibiva@microbio.bas.bg
служебен тел. +359 2 / 979 31 44/03
Ст. н . с. II ст. д-р Емилина Димова Симова
e-mail: lbpmbas@yahoo.com
служебен тел. +359 32 / 603 831
Ст. н . с. II ст. д-р Цонка Атанасова Христозова
e-mail: tshristozova@yahoo.com; lbpmbas@yahoo.com
служебен тел. +359 32 / 603 831
Ст. н . с. II ст. д-р. Дора Миленова Бешкова
e-mail: beshkova@yahoo.com; lbpmbas@yahoo.com
служебен тел. +359 32 / 603 831
Ст. н . с. II ст. д-р Костанца Иванова Павлова
e-mail: konpavlova@yahoo.com; lbpmbas@yahoo.com
служебен тел. +359 32 / 603 831
Ст. н . с. II ст. д-р Гинка Иванова Френгова
e-mail: lbpmbas@yahoo.com
служебен тел. +359 32 / 603 831
Ст. н . с. II ст. д-р Адриана Георгиева Гущерова
e-mail: marine_bg@abv.bg
служебен тел. +359 2 / 979 31 27
Ст.н.с. II ст. д-р Атанас Иванов Павлов
e-mail: at_pavlov@yahoo.com; lbpmbas@yahoo.com;
служебен тел. +359 32 / 642 430
Н.с. д-р Виктория Йорданова Гешева
e-mail: teteven@excite.com
служебен тел. +359 2 / 979 31 34
Н.с. Весела Христова Райковска
e-mail:
служебен тел. +359 2 / 979 31 35/27
Н.с. Лиляна Василева Начева
e-mail: lin1@abv.bg
служебен тел. +359 2 / 979 31 45
Спец. д-р Димка Стоева Тунева
e-mail: lbpmbas@yahoo.com
служебен тел. +359 32 / 603 831
Спец. Мариана Здравкова Коларова
e-mail:
служебен тел. +359 2 / 979 31 03
Спец. Крася Боянова Алексиева
e-mail:
служебен тел. +359 2 / 979 31 03
Спец. Величка Асенова Иванова
e-mail:
служебен тел. +359 2 / 979 31 77
Спец. Юлия Георгиева Кръстева
e-mail:
служебен тел. +359 2 / 979 31 79/80
Техн. Филип Иванов Филипов
e-mail:
служебен тел. +359 2 / 979 31 77/79
Спец. Донка Ангелова Паскалева
e-mail:
служебен тел. +359 2 / 979 31 65
Спец. Калин Кателинов Тодоров
e-mail:
служебен тел. +359 2 / 979 31 79/80
Спец. Март Георгиев Михайлов
e-mail:
служебен тел. +359 2 / 979 31 79/80
Спец. Игнат Янков Димов
e-mail:
служебен тел. +359 2 / 979 31 77/79
Спец. Татяна Стоянова Гочева
e-mail: lbpmbas@yahoo.com
служебен тел. +359 32 / 603 831
Спец. Васил Георгиев Георгиев
e-mail: vasgeorgiev@gmail.com; lbpmbas@yahoo.com
служебен тел. +359 32 / 603 831
Техн. Светла Стойкова Костадинова
e-mail: lbpmbas@yahoo.com
служебен тел. +359 32 / 603 831
Техн. Елка Василева Генова
e-mail: lbpmbas@yahoo.com
служебен тел. +359 32 / 603 831
Лаб. Стефка Василева Василева
e-mail:
служебен тел. +359 2 / 979 31 27
Лаб. Василка Димитрова Ушерова
e-mail: lbpmbas@yahoo.com
служебен тел. +359 32 / 603 831
Научните изследвания в секцията са свързани с метаболизма на прокариотни и еукариотни клетки и възможности за регулацията му с цел създаване на биотехнологии за получаване на биологично-активни вещества за медицината и стартери и адитиви за хранителната промишленост. Предмет на изследване са следните научни проблеми:
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Дрожди – физиология, биохимия и биосинтез на биологично-активни вещества - Ст.н.с. II ст. д-р Цонка Христозова, Ст.н.с. II ст. д-р Костанца Иванова Павлова, Ст.н.с. II ст. д-р Бонка Иванова Цветкова. Изследват се физиологията и биохимия на дрожди (метанолни, хлебопекарски, фуражни) и биосинтез на биологично активни вещества. Изучаване на биологичното разнообразие от психрофилни микроорганизми на о.Ливингстон, Антарктика. Провеждат се изследвания по изолиране, идентифициране и метаболитната способност на психрофилни дрожди за получаване на биологично-активни вещества – ензими, полизахариди, липиди.
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Актиномицети и филаментозни гъби – физиология, биохимия, биосинтез и идентификация на първични и вторични метаболити - Ст.н.с. II ст. д-р Венета Боянова Иванова, д.ф.н, Ст.н.с. II ст. д-р Пенка Първанова Алексиева, Ст. н .с. II ст. д-р Адриана Георгиева Гущерова, н.с. д-р Виктория Йорданова Гешева. Провеждат се изследвания по следните направления: Актиномицети – таксономия, физиология, биохимия и биосинтез на ензими, антибиотици и стимулатори. Изолиране, пречистване и доказване структурите на биологично-активни вещества. Филаментозни гъби - оптимизиране на условията за продукция на екстрацелуларни хидролитични ензими от свободни и имобилизирани клетки на филаментозни гъби; охарактеризиране на технически и пречистени ензимни препарати и изпитване на възможностите им за приложение в биотехнологията.
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Млечно-кисели бактерии – физиология и ресурс за разработване на млечни продукти с висока биологична и хранителна стойност, качество и безопасност - Ст.н.с. II ст. д-р Емилина Димова Симова, Ст.н.с. II ст. д-р Дора Миленова Бешкова, Ст.н.с. II ст. д-р Гинка Френгова – Изследват се физиологията и ресурса на млечнокисели бактерии и решения за реализиране на здравни ползи. Работи се върху създаване на ефективни биоконсорциумни култури за ферментирали млека и сирена с висока физиологична и хранителна стойност чрез: Инкорпориране на антимикробни агенти с широк инхибиторен спектър към селектирани стартерни култури за осъществяване на защитни функции и такива на биоконтролиращи агенти – регулиране на състава на микрофлората, направляване на процесите на формиране и зреене на млечни продукти и участие в биотрансформацията на субстанциите в млякото; Изследване на протеолитичната система на лактобактерии и асоцииране на селектирани щамове лактобацили с високи пептидолитични профили; Нови подходи за разработване на млечни продукти с висока биологична (със здравни ползи) и хранителна стойност, качество и безопасност.
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Амино киселини – биотехнологии за получаването им - Ст.н.с. II ст. д-р Александър Борисов Рътков
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Биологично-активни вещества от растителни in vitro системи - Ст.н.с. I ст. Младенка Паунова Илиева-Стоилова, д.т.н., Ст. н . с. II ст. д-р Атанас Иванов Павлов, Димка Тунева, Васил Георгиев, Татяна Гочева – изследват се различни растителни in vitro системи и приложението им за получаване на ниско-молекулни биологично-активни вещества (включително адитиви и антиоксиданти за хранителната промишленост), ензими и полизахариди. Провеждат се научни изследвания по оптимизация на биосинтетичните процеси, по изолирането, пречистването и идентификацията на получаваните вещества. Специално внимание се отделя на приложението на различни подходи за повишаване добива и ефективността на биосинтетичните процеси (селекция, елиситиране, двуфазни системи за култивиране и др.)
Изследователски проекти:
1. 2001/2003: Betalains production by hairy root cultures from Beta vulgaris
Funding: National Research Foundation of Bulgaria
Project leader: Dr Atanas Pavlov
2. 2000/2005: Alternative Approaches of Bioproduction of Alkaloids and Active Substances from Bulgarian Rare and Threatened Medicinal Plants
Funding: NATO /SfP 974453- Bioproduction/
Project director: Dr Monique Burrus
Project co-director for IM-BAS: Prof. Mladenka Ilieva
3. 2005/2006: Integrated approaches to bioprocess optimization of bioactive substances with plant in vitro systems
Funding: EU – Marie Curie /MERG – CT – 2005 - 021344/
Project leader: Dr. Atanas Pavlov
4. 1999/2001: Biological-active natural products from Antarctic microorganisms and elucidation of their structures
DFG 436Bul 113/107/0/1999-2001
Project leader: Prof. U. Gräfe
Project supervisor: Assoc. Prof. V. Ivanova
5. 2003: Secondary metabolites of microorganisms especially actinomycetes
International collaboration with Göttingen University, Germany
Project leader: Prof. A. Zeeck
Project supervisor: Dr. V. Gesheva
Research staff: Prof. A. Zeeck and his group
Dr. V. Gesheva
6. 2002/2004: Active secondary metabolites from Antarctic microorganisms
DFG 436 BUL113/107/0-2(2002-04).
Project leader: Assoc. Professor V. Ivanova, PhD, DSc.
Collaborator:Hans-Knoell-Institut,Germany(Professor,Dr. U.Graefe)
7. 2000/2003: European Partnership for Vocational Training in Healthy Sound Bioproducts (EURO-BioHealth)
ЕС Programme Leonardo da Vinci, Project № BG/00/C/P/TH/93202
8. 2002/2005: Job Oriented e-Learning in Biotechnology and Environmental Protection (JOBeL-Bio)
ЕС Programme Leonardo da Vinci: № BG/02/B/F/PP-132106
9. 2000/2004: Functional cereal-based products: development, characterization and specific health effects
Project № СС-4/2000 funded by the Bulgarian Ministry of Education and Science.
10. 2002/2004: Application of mixed yeast culture for producing of microbial protein from waste products of food industry
Project № 17/02-N funded by the University of Food Technology.
11. 2001/2004: Investigation of the biosynthesis of enzymes from psychrophilic microorganisms
Project № 37/01 funded by the University of Food Technology
12. 2001/2004: Investigation of lipid composition of microorganisms
Project № 07/01 funded by the University of Plovdiv
13. 2004: Biodiversity, biotic organization and protection of biota of Livingston Island, Antarctica
Project № BA 801 funded by the Bulgarian Ministry of Education and Science
14. 2002/2005: Bacterial mixed cultures, degrading chelate agents and their metal complexes – isolation of Bulgarien sources and identification
Project BE 1205/02 funded by the Bulgarian Ministry of Education and Science
15. 2005/2008: Sdudy of psychrophilic microorganisms for production of biological active substances for food and flavour industres
Project 35/05-N funded by the University of Food Technology.
16. 2004/2007: Intelligent software sensor systems for industry and ecology
Project I-1406/04, National Fund of Scientific Investigations, Ministry of Education and Science, Bulgaria
Project leader for Institute of microbiology – BAS- B. Tzvetkova.
17. Filamentous fungi – high active producers of extracellular alpha-galactosidase for nutrient purposes
Grant MU-B-1519/05 from the National Fund for Scientific Research, Republic of Bulgaria
Project leader: L. Nacheva, SR
Project staff: V. Ivanova, M. Marinova
Project collaborators: Institute of Organic Chemistry with Center of Phytochemistry- BAS
18. Investigation of new hybrid nano materials for obtaining biocatalysts by immobilized whole procariotic and eukaryotic microbial cells
Project supervisor: B. Samuneva, DSc
Project leader: P. Aleksieva, PhD
Project staff: D. Spasova, PhD, E. Bratovanova MS, L. Kabaivanova MS, L. Nacheva SR
Project collaborators: Department of Silicate Technology, University of Chemical Technology & Metallurgy and Institute of Plant Physiology- BAS
19. 2003 – 2005: Разтваряне на кератинова тъкан с оглед ефективното и оползотворяване
Финансиран от МОН – фонд НСНИ: ДОГОВОР СС - 1210
Ръководител : проф. дхм.Петър Недков - ИОХЦФ-БАН
Съръководител : н.с. I ст. д-р Адриана Гущерова – ИМ-БАН
Proteolytic profiles of lactic acid bacteria for fermented milks
Grant: CC-14-06/04, National Science Fund, Ministry of Education and Science, Sofia, Bulgaria
Project leader: Assoc. Prof. E. Simova
Partner: University of Food Technology, Plovdiv, Bulgaria; LB Bulgaricum PLC, R&D Center, Sofia, Bulgaria
21. Bacteriocin-synthesizing lactobacteria in starter cultures for probiotic fermented milks
Grant: Б-14-01/04, National Science Fund, Ministry of Education and Science, Sofia, Bulgaria
Project leader: Assoc. Prof. D. Beshkova
Partner: University of Food Technology, Plovdiv, Plovdiv; LB Bulgaricum PLC, R&D Center, Sofia, Bulgaria
22. Bioconversion of nature substances for production of carotenoid-protein products for agriculture
Grant: CC-12-03/02, National Science Fund, Ministry of Education and Science, Sofia, Bulgaria
Project leader: Assoc. Prof. G. Frengova
Partner: University of Food Technology, Plovdiv, Bulgaria; LB Bulgaricum PLC., R&D Center, Sofia, Bulgaria
23. Mutual metabolism of lactic acid bacteria and yeast in starters for fermented milk types with medical properties
Grant: CC 817/98, National Science Fund, Ministry of Education and Science, Sofia, Bulgaria
Project leader: Assoc. Prof. E. Simova
Partner: University of Food Technology, Plovdiv, Bulgaria; LB Bulgaricum PLC., R&D Center, Sofia, Bulgaria
Recent Publications:
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Aleksieva, P., Spasova, D., Radoevska, S. Acid phosphatase distribution and localization in the fungus Humicola lutea. Z. Naturforsch. 2003, 58c, 239-243.
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Aleksieva, P., Tchorbanov, B., Michailova, L., Nacheva, L. Improvement of acid phosphatase production by immobilization of Humicola lutea mycelium in polyurethane sponge. World J. Microbiol. Biotechnol. 2003, 19, 247-253.
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Aleksieva, P., Nacheva, L., Panayotov A., Tchorbanov, B. Exopolysaccharides from fungal source using low carbohydrates solutions as fermentation substrates. Compt. Rend. Acad. Bulg. Sci. 2004, 57(2), 91-94.
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Angelov, A., Gotcheva, V., Hristozova, Ts., Gargova, S. Application of pure and mixed probiotic lactic acid bacteria and yeast cultures for oat fermentation. J. Science Food and Agriculture 2005, 85, 2134-2141.
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Berkov, S., Pavlov, A. A rapid densitometric method for the analysis of hyoscyamine and scopolamine in solanaceous plants and their transformed root cultures. Phytochem Analysis 2004, 15, 141-145.
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Berkov, S., Pavlov, A., Ilieva, M., Burrus, M., Popov, S., Stanilova, M. GC/MS of alkaloids in Leucojum aestivum plants and their in vitro cultures. Phytochem Analysis 2005, 16, 98-103.
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Berkov, S., Pavlov, A., Kovatcheva, P., Stanimirova, P., Philipov, S. Alkaloid Spectrum in Diploid and Tetraploid Hairy Root Cultures of Datura stramonium. Z. Naturforsh. 2003, 58c, 42-46.
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Beshkova, D., Simova, E., Frengova, G., Simov, Z., Dimitrov, Zh. Production of volatile aroma compounds by kefir starter cultures. Int. Dairy J. 2003, 13(7), 529-535.
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Beshkova, D.M., Simova, E.D., Frengova, G.I., Simov, Z., Spasov, Z. Effect of oxygen on batch yogurt cultures. World J. Microbiol. Biotechnol., 2002, 18, 3, 361-365.
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Beshkova, D.., Simova, E., Simov, Z., Frengova, G., Spasov, Z. Pure cultures for making kefir. Food Microbiol. 2002, 19, 537-544.
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Kovatcheva, E., Koleva, I., Ilieva, M., Pavlov, A., Mincheva, M., Konuslieva, M. Antioxidant activity of extracts from L. vera MM cell cultures. Food Chemistry 2001, 72, 295 – 300.
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Frengova, G., Simova, E., Beshkova, D. Improvement of carotenoid-sinthesizing yeast by chemical mutagenesis. Z. Naturforsch. 2004, 59c, 99-103.
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Frengova, G., Simova, E., Beshkova, D. Carotenoid production by lactosone-gative yeast co-cultivated with lactic acid bacteria in whey ultrafiltrate. Z. Naturforsch. 2003, 58c, 562-567.
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Frengova, G., Simova, E., Beshkova, D. -Carotene-rich-protein preparation and exopolysaccharide production by Rhodotorula rubra GED8 grown with yogurt starter culture. Z. Naturforsch. 2006 (in press).
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Frengova, G., Simova, E., Beshkova, D. Use of whey ultrafiltrate as a substrate for production of carotenoids by the yeast Rhodotorula rubra. Appl. Biochem. Biotechnol. 2004, 112, 3, 133-141.
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Frengova, G., Simova, E., Beshkova, D., Simov, Z. Exopolysaccharides produ-ced by lactic acid bacteria of kefir grains. Z. Naturforsch. 2002, 57c, 805-810.
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Georgiev, M., Kuzeva, S., Pavlov, A., Kovacheva, E., Ilieva, M. Enhanced Rosmarinic Acid Production by Lavandula vera MM Cell Suspension Culture through Elicitation with Vanadyl Sulphate. Z. Naturforsch. 2006 (in press).
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Georgiev, M., Pavlov, A., Ilieva, M. Rosmarinic acid production by Lavandula vera MM cell suspension: the effect of temperature. Biotechnol. Letters 2004, 26, 855-856.
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Gesheva, V. Formation and regeneration of Streptomyces hygroscopicus protoplasts. Сборник 10-ти конгрес по микробиология, 2002 (под печат).
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Gesheva, V. Rhizosphere microflora of some citrus as a source of antagonistic actinomycetes. Eur. J. Soil Biol. 2002, 38, 85-88.
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Gesheva, V. Microbiota of subantarctic soils from South Georgia Island. Cyprus J. Sci. 2005, 3, 75-81.
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Gesheva, V., Ivanova, V., Gesheva, R. Effects of nutrients on the production of AK-111-81 macrolide antibiotic by Streptomyces hygroscopicus. Microbiological Research, 2005, 160, 243-248.
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Gocheva, J., Krumova, E., Slokoska, L., Gesheva, V., Angelova, M. Isolation of filamentous fungi from Antarctica. Compt. Rend. Acad. bulg. Sci. 2005, 58, 403-408.
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Goshev, I., Gousterova, A., Vasileva-Tonkova, E., Nedkov, P. Characterization of the enzyme complexes produced by two newly isolated thermophylic actinomycete strains during growth on collagen-rich materials. Process Biochem. 2005, 40, 1627-1631.
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Gotcheva V., M. Guo, E. Hristozova, Ts. Hristozova, Z. Roshkova, A. Angelov. Assessment of potential probiotic properties of Lactic acid bacteria and yeast strains. Food Biotechnol. 2002, 16(3), 211-225.
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Gousterova, A., Braikova, D., Goshev, I., Christov, P., Tishinov, K., Vasileva-Tonkova, E., Haertlé, Т., Nedkov, P. Degradation of keratin and collagen containing wastes by newly isolated thermoactinomycetes or by alkaline hydrolysis. Lett. Appl. Microbiol. 2005, 40, 335-340.
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Gushterova, A., Vasileva-Tonkova, E., Dimova, E., Nedkov, P., Haertle, T. Keratinase production by newly isolated Antarctic actinomycete strains. World J. Microbiol. Biotechnol. 2004, 21, 6-7, 831-834.
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Gushterova, A., V. Ivanova, K. Aleksieva, M. Kolarova, B. Schlegel, U. Graefe. Taxonomic investigations of the Antarctic mesophilic strain 2BG, producer of secondary metabolites. J. Biotechnol. Biotechnological Equipment 2004, 18, 72-76.
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Hoshino,Y., Ivanova, V., Yazawa, K., Ando, A., Mikami, Y., Zaki, S., Karam, Z., Youssef, Y., Graefe, U. Queenslandon, a new antifungal compound produced by Chrysosporium queenslandicum: Production, isolation and structure elucidation. J. Antibiotics 2002, 55, 516-520.
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Hristozova, Ts., Angelov, A., Tzvetkova, B., Paskaleva, D., Gotcheva, V., Gargova, S., Pavlova, K. Effect of furfural on carbon metabolism key enzymes of lactose-assimilating yeasts. Enzyme Microb. Technol. 2006 (in press).
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Hristozova, Ts., Michailova, L., Tuneva, D., Gotcheva, V., Angelov, A., Roshkova, Z. Mutant Hansenula polymorpha with constitutive alcohol oxidase and peroxisome biosynthesis. Z. Naturforsch. 2002, 57c, 858-862.
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Hristozova, Ts., Rasheva, T., Nedeva, T., Kujumdzieva, A. Superoxide dismutase duringng glucose repression of Hansenula polymorpha CBS 4732. Z. Naturforsch. 2002, 57c , 313-318.
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Ilieva, M., Pavlov, A., Kovatcheva, E. Further Research into Lavandula Species: Cell Cultures of Lavandula vera and Rosmarinic Acid Production - In: Genus Lavandula – series “Medicinal and Aromatic Plants (M. Lis-Balchin - ed) – Taylor & Francis Publishers 2002.
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Ilieva, M., Pavlov, A., Bakalova, A. Phosphodiesterases production in an Aqueous Two-phase system by N. tabacum 1507 – Appl. Biochem. Biotechnol. 2001, 90(3), 261-272.
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Kovatcheva, E., Koleva, I., Ilieva, M., Pavlov, A., Mincheva, M., Konuslieva, M. Antioxidant activity of extracts from L. vera MM cell cultures. Food Chemistry 2001, 72, 295 – 300.
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Pavlov, A., Ilieva, M., Mincheva, M. Realease of rosmarinic acid by Lavandula vera MM cell suspension in two-phase culture systems. World J. Microbiol. Biotechnol. 2001, 17, 417-421.
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Georgiev, V. Betalains biosynthesis by transformed root cultures from Beta vulgaris: influence of main components of the nutrient medium. Scientific works UFT, Plovdiv, Vol. LI 2004, (3), 183-189.
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Pavlov, A., Georgiev, M., Georgiev, V., Gocheva, T., Tuneva, D., Ilieva, M., Burrus, M. Cultivation of Leucojum aestivum shoot cultures in bioreactor. Scientific Works UFT 2005, 52(2), 305-310.
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Georgiev, M., Georgiev, V., Gocheva, T., Tuneva, D., Pavlov, A., Ilieva, M., Burrus, M. Optimization of nutrient medium composition for galanthamine biosynthesis by Leucojum aestivum shoot culture. Scientific Works UFT 2005 ,52(2), 311-315.
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Ilieva, M., Pavlov, A., Bakalova, A. Phosphodiesterases production in an Aqueous Two-phase system by Nicotiana tabacum 1507. Appl. Biochem. Biotechnol. 2001, 90(3), 261-272.
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Ilieva, M., Kratchanova, M., Pavlova, E., Dimova, T., Petrova, D., Pavlov, A., Mihneva, M. Polygalacturonase adnd pectinmethylesterase activities during growth of N. tabacum 1508 cell suspension. Scientific Works of Higher Institute of Food and Flavour Industries, XLVI: 2001, 185-190.
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