А дали не е B12? — Епидемия от погрешни диагнози

302 2. Dharmarajan, T.S., Norkus, E.P. Approaches to vitamin B
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deficiency: Early treatment may prevent devastating complications.
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3. Ibid.
4. http://www.cdc.gov/ncbddd/B12/intro.html
5. MedicineNet.com
6. http://www.cdc.gov/ncbddd/B12/intro.html
7. Antony, A.C. Vegetarianism and vitamin B
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(cobalamin)
deficiency. American Journal of Clinical Nutrition vol. 78. №1, 3–6, July
2003.
8. Green, R. Unreliability of current assays to detect cobalamin deficiency: „nothing gold can stay“ Blood 2005, 105:910-911.
9. Solomon, L.R. Cobalamin-responsive disorders in the ambulatory care setting: unreliability of cobalamin, methylmalonic acid, and homocysteine testing. Blood 2005, 105:978-985.
10. Solomon, L.R. Disorders of cobalamin (Vitamin B
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11. http://www.cdc.gov/ncbddd/B12/summary.html
12. http://www.cdc.gov/ncbddd/B12/summary.html
13. Antony, A.C. Megaloblastic anemias. Във: R. Hoffman et al. (3rd ed.), Hematology: Basic Principles and Practice (pp. 457–467) 2000,
Philadelphia: Churchill, Livingstone; и Savage, D.G., Lindenbaum, J.,
Stabler, S.P., Allen, R.H. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. American Journal of Medicine 1994, 96:239-246; и Norman,
E.J., Morrison, J.A. Screening elderly populations for cobalamin (vitamin
B
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14. Dharmarajan, T.S., Norkus, E.P. Approaches to vitamin B
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26. Ibid.

304 27. Ibid.
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29. Ibid.
30. Ibid.
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Medicine 1993, 94:589-594.
37. Lee, G.R. Pernicious anemia and other causes of vitamin B
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38. Ibid.
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306
[1]
В някои страни също се използва pmol/l вместо pg/ml.
↑
[2]
Според учените, преобразуването на цианокобаламина в активни коензимни форми (метилкобаламин и аденозилкобаламин)
става на приблизително четири стъпки. [40] Метилкобаламинът се намира в кръвната плазма, гръбначномозъчната течност и цитозола.
Аденозилкобаламинът преобладава в клетъчните тъкани, където се задържа от митохондриите. Ако някакъв дефект не позволява преобразуването на цианокобаламина 6 метилкобаламин, наличният
B
12
е неизползваем и остава в кръвната плазма, ликвора и цитозола.
↑

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