Научни трудове на проф. С. Д. Стоев – по хронологичен ред



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Цитирана статия: Stoev, S. D., V. Koynarsky, P. G. Mantle, Clinicomorphological studies in chicks fed ochratoxin A while simultaneously developing coccidiosis, Veterinary Research Communications, 2002, 26, 189-204


  1. O’Brien E., Dietrich DR, Ochratoxin A: The continuing enigma, CRITICAL REVIEWS IN TOXICOLOGY 35 (1): 33-60 JAN 2005.

  2. Oswald, I.P., Marin, D.E., Bouhet, S., Pinton, P., Taranu, I., Accensi, F. Immunotoxicological risk of mycotoxins for domestic animals, Food Additives and Contaminants, 22 (4): pp. 354-360, 2005.

  3. Al-Anati, L., Petzinger, E., Immunotoxic activity of ochratoxin A, Journal of Veterinary Pharmacology and Therapeutics, 29 (2), 79-90, 2006.

  4. De Schothorst, Mycotoxinen: Deskstudie naar de belasting van ййnmagige landbouwhuisdieren en de overdracht naar het dierlijk product, Productschap Diervoeder, Kwaliteitsreeks, 89, 1-80, JUNE 2003.

  5. Gupta, S., Jindal, N., Khokhar, R.S., Asrani, R.K., Ledoux, D.R., Rottinghaus, G.E., Individual and combined effects of ochratoxin a and Salmonella enterica serovar Gallinarum infection on pathological changes in broiler chickens, Avian Pathology 37 (3), pp. 265-272, 2008.

  6. Pfohl-Leszkowicz, A., Manderville, R.A., Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans , Molecular Nutrition and Food Research 51 (1), pp. 61-99, 2007

  7. Mwanza Mulunda, An investigation in South African domesticated animals, their products and related health issues with references to mycotoxins and fungi, Magister Technologiae, Faculty of Science, University of Johannesburg, 1-185, 2007.

  8. Madhuri?D., ?Verma?P.C., Effect of Ochratoxin-A on pathology of hydropericardium syndrome in broiler chicken, Indian Journal of Veterinary Pathology, Year : 2009, Volume : 33, Issue : 1


Цитирана статия: Stoev, S. D., M. Stefanov, St. Denev, B. Radic, A-M. Domijan, M. Peraica, Experimental mycotoxicosis in chickens induced by ochratoxin A and penicillic acid and intervention by natural plant extracts, Veterinary Research Communications, 28, 8, 2004, 727-746


  1. IZVJEЉTAJ O RADU INSTITUTA U 2005. GODINI, ANNUAL REPORT FOR 2005 OF THE INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH, ZAGREB, Arh Hig Rada Toksikol, vol 57, 2006, 79-141.

  2. Artichoke Powder, Clinical Documentation and Research, Antioxidant & Cellular Protective Actions, Raintree Nutrition Inc, Carson City, Nevada 89701.

  3. Artichoke Extract, Clinical Documentation and Research, Antioxidant & Cellular Protective Actions, Raintree Nutrition Inc, Carson City, Nevada 89701.

  4. Bianco, V.V., Present and prospect of utilization of fresh and processed artichoke, 2007 Acta Horticulturae 730, pp. 23-37, 2007

  5. Hanif, N.Q., Muhammad, G., Siddique, M., Khanum, A., Ahmed, T., Gadahai, J.A., Kaukab, G., Clinico-pathomorphological, serum biochemical and histological studies in broilers fed ochratoxin A and a toxin deactivator (Mycofix® Plus) , British Poultry Science 49 (5), pp. 632-642, 2008.

  6. Elaroussi, M.A., Mohamed, F.R., Elgendy, M.S., El Barkouky, E.M., Abdou, A.M., Hatab, M.H., Ochratoxicosis in broiler chickens: Functional and histological changes in target organs, International Journal of Poultry Science 7 (5), pp. 414-422, 2008.

  7. Ahmed, H.H., Mannaa, F., El-Sayed, E.M., Ameliorative effect of artichoke (Cynara scolymus L.) extracts on creatine monohydrate-induced renal dysfunction in male rats , Deutsche Lebensmittel-Rundschau 104 (1), pp. 29-36, 2008.

  8. Sawale, G.K., Gosh, R.C., Ravikanth, K., Maini, S., Rekhe, D.S., Experimental mycotoxicosis in layer induced by Ochratoxin A and its amelioration with herbomineral toxin binder 'Toxiroak' , 2009 International Journal of Poultry Science 8 (8), pp. 798-803, 2009

  9. Pfohl-Leszkowicz, A., Ochratoxin a and aristolochic acid involvement in nephropathies and associated urothelial tract tumours, 2009 Arhiv za Higijenu Rada i Toksikologiju 60 (4), pp. 465-483, 2009

  10. Löhr, G., Deters, A., Hensel, A., In vitro investigations of Cynara scolymus L. extract on cell physiology of HepG2 liver cells , 2009 Revista Brasileira de Ciencias Farmaceuticas/Brazilian Journal of Pharmaceutical Sciences 45 (2), pp. 201-208, 2009

  11. E. M. El Barkouky; F. R. Mohamed; A. M. Atta; A. M. Abu Taleb; M.A.ElMenawey; and M. H. Hatab, EFFECT OF SACCHAROMYCES CEREVISIAE AND VITAMIN C SUPPLEMENTATION ON PERFORMANCE OF BROILERS SUBJECTED TO OCHRATOXIN A CONTAMINATION, Egypt. Poult. Sci. Vol (30) (I): (89-113), 2010.

  12. C. K. Girish, T. K. Smith, Impact of feed-borne mycotoxins on avian cell-mediated and humoral immune responses, World Mycotoxin Journal, 1(2): 105-121, 2008.

  13. Gisely Cristiny Lopes; Andrйia Cristina Conegero Sanches; Cleyton Eduardo Mendes de Toledo; Ana Cristina Isler; Joгo Carlos Palazzo de Mello, Determinaзгo quantitativa de taninos em trкs espйcies de Stryphnodendron por cromatografia lнquida de alta eficiкncia, Braz. J. Pharm. Sci., vol.45, no.1, São Paulo, Jan./Mar., 2009.


Цитирана статия: Stoev, S. D., Djuvinov D., Mirtcheva T., Pavlov D., Mantle P., Studies on some feed additives giving partial protection against ochratoxin A toxicity in chicks, Toxicology Letters, 2002, 135, 1-2, 33-50


  1. Bursian SJ, Mitchell RR, Yamini B, Fitzgerald SD, Murphy PA, Fernadez G, Rottinghaus GE, Moran L, Leefers K, Choi I, Efficacy of a commercial mycotoxin binder in alleviating effects of ochratoxin A, fumonisin B-1, moniliformin and zearalenone in adult mink, VETERINARY AND HUMAN TOXICOLOGY 46 (3): 122-129 JUN 2004.

  2. Van Rensen, I., Wittemer, S.M., Artichoke - Cynara cardunculus subsp. flavescens (formerly Cynara scolymus) | [Cynara cardunculus subsp. flavescens (bisher Cynara scolymus) - Die Artischocke], Zeitschrift fur Phytotherapie, 24 (6): 267-276, 2003.

  3. Amйzqueta, S., Gonzбlez-Peсas, E., Murillo-Arbizu, M., Lуpez de Cerain, A., Ochratoxin A decontamination: A review, Food Control 20 (4), pp. 326-333, 2009

  4. Hanif, N.Q., Muhammad, G., Siddique, M., Khanum, A., Ahmed, T., Gadahai, J.A., Kaukab, G., Clinico-pathomorphological, serum biochemical and histological studies in broilers fed ochratoxin A and a toxin deactivator (Mycofix® Plus) , British Poultry Science 49 (5), pp. 632-642, 2008

  5. Gupta, S., Jindal, N., Khokhar, R.S., Asrani, R.K., Ledoux, D.R., Rottinghaus, G.E., Individual and combined effects of ochratoxin a and Salmonella enterica serovar Gallinarum infection on pathological changes in broiler chickens, Avian Pathology 37 (3), pp. 265-272, 2008

  6. Ahmed, H.H., Mannaa, F., El-Sayed, E.M., Ameliorative effect of artichoke (Cynara scolymus L.) extracts on creatine monohydrate-induced renal dysfunction in male rats, Deutsche Lebensmittel-Rundschau 104 (1), pp. 29-36, 2008

  7. Abdo, Z.M.A., Radwan, N.L., Selim, N.A, The effect of artichocke leaves meal on the utilization of dietary energy for broiler chicks , International Journal of Poultry Science 6 (12), pp. 973-982, 2007

  8. Radwan, N.L., Abdo, Z.M.A., Hassan, R.A., Effect of feeding artichoke leaves meal on productive and reproductive performance of Mandarah hens , International Journal of Poultry Science 6 (11), pp. 826-834, 2007.

  9. Elaroussi, M.A., Mohamed, F.R., El Barkouky, E.M., Atta, A.M., Abdou, A.M., Hatab, M.H., Experimental ochratoxicosis in broiler chickens , Avian Pathology 35 (4), pp. 263-269, 2006

  10. Njobeh, Literature Review, PhD Thesis, Chapter 2, 2008, pp 2-86.

  11. Sawale, G.K., Gosh, R.C., Ravikanth, K., Maini, S., Rekhe, D.S., Experimental mycotoxicosis in layer induced by Ochratoxin A and its amelioration with herbomineral toxin binder 'Toxiroak' , 2009 International Journal of Poultry Science 8 (8), pp. 798-80, 2009

  12. Meissonnier, G.M., Raymond, I., Laffitte, J., Cossalter, A.M., Pinton, P., Benoit, E., Bertin, G., (...), Oswald, I.P., Dietary glucomannan improves the vaccinal response in pigs exposed to aflatoxin B1 or T-2 toxin, 2009 World Mycotoxin Journal 2 (2), pp. 161-172, 2009

  13. Amézqueta, S., González-Peñas, E., Murillo-Arbizu, M., López de Cerain, A., Ochratoxin A decontamination: A review, 2009 Food Control 20 (4), pp. 326-333, 2009

  14. Carmen Solcan, I. Coman, Gh. Solcan, L. Miron, O. Z. Oprean, HISTOLOGICAL AND ULTRASTRUCTURAL LESIONS OF THE KIDNEY IN EXPERIMENTAL OCHRATOXICOSIS OF BROILER CHICKENS, Bulletin UASVM, Veterinary Medicine 65(1), 2008.

  15. E. M. El Barkouky; F. R. Mohamed; A. M. Atta; A. M. Abu Taleb; M.A.ElMenawey; and M. H. Hatab, EFFECT OF SACCHAROMYCES CEREVISIAE AND VITAMIN C SUPPLEMENTATION ON PERFORMANCE OF BROILERS SUBJECTED TO OCHRATOXIN A CONTAMINATION, Egypt. Poult. Sci. Vol (30) (I): (89-113), 2010.

  16. Surai, P. F., Dvorska, J. E., Effects of mycotoxins on antioxidant status and immunity, The mycotoxin blue book, Diaz, D. E (Ed), CABI Abstract, Nottingham University Press, 2006.

  17. ESTELA DE OLIVEIRA NUNES, POPULAЗГO DE FUNGOS FILAMENTOSOS E SUA RELAЗГO COM MICOTOXINAS PRESENTES NA UVA E NO VINHO DE SANTA CATARINA, UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO TECNOLУGICO, PhD-thesis, DEPARTAMENTO DE ENGENHARIA QUНMICA E DE ALIMENTOS, PROGRAMA DE PУS-GRADUAЗГO EM ENGENHARIA QUНMICA, Florianуpolis – SC, pp 1-198, 2008.



Цитирана статия: Stoev, S. D., Ultrastructural and antidote investigations into the experimental intoxication of chickens with ochratoxin A and penicillic acid, Folia Veterinaria, 2000, 44, 2, 85-90


  1. Marion ROUVIER, L’OCHRATOXINE A :NATURE, ORIGINE ET TOXICITE, THESE pour obtenir le grade de DOCTEUR VETERINAIRE, DIPLOME D’ETAT, l’Université Paul-Sabatier de Toulouse, pp 1-144, 2002.

  2. Ahmed, H.H., Mannaa, F., El-Sayed, E.M., Ameliorative effect of artichoke (Cynara scolymus L.) extracts on creatine monohydrate-induced renal dysfunction in male rats , Deutsche Lebensmittel-Rundschau 104 (1), pp. 29-36, 2008


Цитирана статия: Stoev, S. D., G. Angelov, D. Pavlov and L. Pirovski, Some Antidotes and Paraclinical Investigations in Experimental Intoxication with Ochratoxin A and Penicillic Acid in Chicks, Veterinarski Arhiv, 69, 4, 1999, 179-189


  1. SANDOVAL G.L., FERNANDEZ R.J., TERRAES J.C., REVIDATTI F.A., Efectos de la suplementaciуn con extracto de alcachofa (Cynara scolimus L.) y cloruro de colina sobre algunas variables bioquнmicas en pollos, In Vet, vol. 6, No1, article 3, 2004, 1514-6634 (1668-3498 on line)

  2. TERRAES J.C., REVIDATTI F.A., SANDOVAL G.L., FERNANDEZ R.J, Efectos de la suplementaciуn con extracto de alcachofa (Cynara scolimus L.) y cloruro de colina en la producciуn de pollos parrilleros sometidos a estrйs, In Vet, vol. 6, No1, article 4, 2004, 1514-6634 (1668-3498 on line)

  3. Terraes Juan C., Fernбndez Ricardo J., Revidatti Fernando, Sandoval Gladis L., Zbinden Carlos, Efectos de la suplementaciуn con extracto de alcachofa (Cynara scolimus L.) y cloruro de colina sobre los нndices productivos en pollos parrilleros sometidos a una maniobra inductora de estrйs, In Vet, vol. 6, No1, 2004, 1514-6634 (1668-3498 on line)


Цитирана статия: Stoev, S. D., I. Kunev, B. Radic, Hematological, biochemical and toxicological investigations in spontaneous cases of mycotoxic nephropathy (ochratoxicosis) in pigs, Bulgarian Journal of Agricultural Science, 3, 1997, 507-516


  1. Pfohl-Leszkowicz A, Petkova-Bocharova T, Chernozemsky IN, Castegnaro M, Balkan endemic nephropathy and associated urinary tract tumours: a review on aetiological causes and the potential role of mycotoxins, FOOD ADDITIVES AND CONTAMINANTS, 19 (3): 282-302 MAR 2002.

  2. IZVJEЉTAJ O RADU INSTITUTA U 1998. GODINI, ANNUAL REPORT FOR 1998 OF THE INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH, ZAGREB, Arh Hig Rada Toksikol, vol 50, 1999, 87-159.

  3. Pfohl-Leszkowicz, A., Manderville, R.A., Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans , Molecular Nutrition and Food Research 51 (1), pp. 61-99, 2007


Цитирана статия: Stoev, S. D., Some Metric, Antidote and Pathomorphological Investigations in Experimental Intoxication with Ochratoxin A and Penicillic Acid in Chicks, Bulgarian Journal of Agricultural Science, 4, 1998, 551-563.


  1. Mahmoud Abd-Elmoneim Abd-Elsalam Sharaf-Eldin, Studies on the Effect of Some Agricultural Treatments on Growth and Productivity of Artichoke (Cynara cardunculus var. scolymus (L.) Fiori) and their Relation to Earliness and Physical and Chemical Characters of Heads, Vollstдndiger Abdruck der von der Fakultдt Wissenschaftszentrum Weihenstephan fьr Ernдhrung, Landnutzung und Umwelt der Technischen Universitдt Mьnchen zur Erlangung des akademischen Grades eines Doktors der Agrarwissenschaften genehmigten Dissertation, Department fьr Pflanzenwissenschaften, Lehrstuhl fьr Gemьsebau, 2002, pp 1-126.


Цитирана статия: Stoev, S. D., G. Angelov and D. Pavlov, Some Paraclinical Investigations in Experimental Intoxication with Ochratoxin A and Penicillic Acid in Chicks, Bulgarian Journal of Agricultural Science, 4, 1998, 565-573


  1. Mahmoud Abd-Elmoneim Abd-Elsalam Sharaf-Eldin, Studies on the Effect of Some Agricultural Treatments on Growth and Productivity of Artichoke (Cynara cardunculus var. scolymus (L.) Fiori) and their Relation to Earliness and Physical and Chemical Characters of Heads, Vollstдndiger Abdruck der von der Fakultдt Wissenschaftszentrum Weihenstephan fьr Ernдhrung, Landnutzung und Umwelt der Technischen Universitдt Mьnchen zur Erlangung des akademischen Grades eines Doktors der Agrarwissenschaften genehmigten Dissertation, Department fьr Pflanzenwissenschaften, Lehrstuhl fьr Gemьsebau, 2002, pp 1-126.


Цитирана статия: Стоев, С., Експериментална микотоксична нефропатия при свине 1. Патоморфологични проучвания, Ветеринарна медицина, 3, 1-2, 1997, 102-107.


  1. Pfohl-Leszkowicz A, Petkova-Bocharova T, Chernozemsky IN, Castegnaro M, Balkan endemic nephropathy and associated urinary tract tumours: a review on aetiological causes and the potential role of mycotoxins, FOOD ADDITIVES AND CONTAMINANTS, 19 (3): 282-302 MAR 2002.

  2. Dietrich DR, O'Brien E, Stack ME, Heussner AH, Species- and sex-specific renal cytotoxicity of Ochratoxin A and B in vitro, EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 53 (2-3): 215-225 JUN 2001.

  3. Pfohl-Leszkowicz, A., Manderville, R.A., Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans , Molecular Nutrition and Food Research 51 (1), pp. 61-99, 2007


Цитирана статия: Stoev, S., E. Creppy, B. Hald, B. Radic, Examination of contamination levels of ochratoxin A in feed and serum from regions with high percentage of nephropathy in pigs, Proceedings of the 9th International Congress in Animal Hygiene, Volume 2, 17-21 August, 1997, Helsinki, Finland, pp 840-843


  1. IZVJEЉTAJ O RADU INSTITUTA U 1998. GODINI, ANNUAL REPORT FOR 1998 OF THE INSTITUTE FOR MEDICAL RESEARCH AND OCCUPATIONAL HEALTH, ZAGREB, Arh Hig Rada Toksikol, vol 50, 1999, 87-159.


Цитирана статия: Stoev, S., Food Safety and some foodborne mycotoxicoses, Vet Africa 2007 Congress, 27-28 July, 2007, Johannesburg, South Africa


  1. Njobeh, Studies on mycotoxins in human foods in Cameroon, PhD Thesis, Chapter 5, pp. 129-165, 2008


Цитирана статия: Stoev, S. D., Mycotoxic nephropathies in farm animals – diagnostics, risk assessment and prevеntive measures, In: Effect of Mycotoxins in Farm Animals, Chapter 8, Isabelle Oswald, Ionelia Taranu (Eds), S.G. Pandalai (Managing Editor), pp. 155-195, Transworld Research Network, 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India, pp. 155-195, 2008.


  1. Njobeh, Studies on mycotoxins in human foods in Cameroon, PhD Thesis, Chapter 5, pp. 129-165, 2008


Цитирана статия: Daskalov H., N.Grozeva, S.Stoev, Hepatic Lipoidosis in Rainbow Trout (Oncorhynchus mykyss, Walbaum) - influence of pathomorphological changes upon flesh quality, Bulletin of European Association of Fish Pathologists, 1999, 19, 1, 20-23.


  1. Tucker JW, Lellis WA, Vermeer GK, The correlation between liver dry matter and liver lipid in cultured juvenile red drum fed various diets, NORTH AMERICAN JOURNAL OF AQUACULTURE, 63 (1): 38-44 JAN 2001.

  2. Гаврюсева Т. В., Патоморфологические изменения при алиментарном токсикозе у молоди тихоокеанских лососей рода Oncorhynchus на Камчатке, Исследования водных биологических ресурсов Камчатки и Северо-западной части Тихого океана, 9, 171-184, 2007.


Цитирана статия: Стоев, С., Микотоксична нефропатия при свинете - етиология, патогенеза, клиникоморфологични и ултраструктурни промени, Вет. мед. науки, 26, 2, 1992, 85-90.


  1. Джуров А., П. Белемезов, Периренален едем при прасета, Ветеринарна сбирка, 5-6, 21-23, 1993.


Цитирана статия: Стоев, С. и Д. Стойков, Микотоксична нефропатия (охратоксикоза) по свинете, Вет. мед. науки, 27, 2, 1993, 57-61.


  1. Mantle P., Plant surface micro-organisms as sources of compounds toxic for humans and domestic animals, In: Aerial plant Surface Microbiology, Edited by Morris et al, Plenum Press, New York, 221-232, 1996.

  2. Milićević Dragan R., Jurić Verica B., Vuković Dubravka Z., Mandić Miodrag M., Baltić Tatjana M., Residue of ochratoxin A in swine tissues: Risk assessment, Archive of Oncology, 2009, vol. 17, br. 3-4, str. 56-60, 2009.


Цитирана статия: Даскалов, Х., Л. Лозанов, С. Стоев, Патоморфологични изменения във вътрешните органи на едногодишни пъстърви (Salmo gairdneri irideus Gibb.) хранени с нестандартни фуражи, IVти Симпозиум на младите научни работници и специалисти в системата на ДО "Ветеринарно дело" на тема "Актуални въпроси на ветеринарно-медицинската наука и практика", 27-28 Октомври, 1988, Казанлък, Сборник доклади, 250-259


  1. Шошков Д., Х. Даскалов, Влияние на качеството на фуража върху трансаминазите в кръвта на едногодишна дъгова пъстърва (Salmo gairdnery Rich), Ветеринарномедицински науки, 27, 1, 51-56, 1993.

  2. Даскалов Х., Х. Георгиев, В. Лашева, Левкоцитна формула на дъговата пъстърва след хранене с недоброкачествени фуражи, Ветеринарномедицински науки, 28, 3, 27-33, 1994.

  3. H. Daskalov, P A W. Robertson, and B. Austin, Influence of oxidized lipids in diets on the development of rainbow trout fry syndrome, Journal of Fish Diseases, Volume 23 Issue 1, Pages 7-14.


Цитирана статия: Daskalov H., Stoev S. 1995. Pathomorphological changes in rainbow trout fed with low–quality diets, Vet. Med. V. 2. P. 248–250


  1. Гаврюсева Т. В., Патоморфологические изменения при алиментарном токсикозе у молоди тихоокеанских лососей рода Oncorhynchus на Камчатке, Исследования водных биологических ресурсов Камчатки и Северо-западной части Тихого океана, 9, 171-184, 2007.

Short CV of Prof. S. Stoev (English)
Education (University, Faculty, Year of Graduation):

Faculty of Veterinary medicine, High Institute of Zootechnics and Veterinary Medicine (the former name of Trakia University), Stara Zagora, Bulgaria - 1980-1985. Diploma of Doctor in Veterinary Medicine (DVM serie A84, No 016653, Reg N 4881) from 29.11.1985.


Titles/Qualifications/Year:

Diploma of Ph.D. (N 25258) from 21.04.1998 (code 03.01.03 – Pathologoanatomy and cytopathology) - High Certifying Commission, Council of Ministers, Sofia, Bulgaria

Diploma of Associated Professor in “Veterinary pathology” (N 19909) from 15.10.1999 (code 03.01.03 – Pathologoanatomy and cytopathology) - High Certifying Commission, Council of Ministers, Sofia, Bulgaria.

Diploma of D.Sc. in “Veterinary Science” (N 29367) from 25.06.2004 (code 04.03.06 – Pathology of animals) - High Certifying Commission, Council of Ministers, Sofia, Bulgaria.

Diploma of Professor in “Pathologoanatomy and cytopathology” (N 24549) from 19.06.2007 (code 03.01.03 – Pathologoanatomy and cytopathology) – High Certifying Commission, Council of Ministers, Sofia, Bulgaria.
National Experience (institution, duration, year):

1) District Veterinary Doctor (01.06.1986 – 01.07.1987) – working with pigs, cattle, sheep and chickens

2.) Professor in department of Pathology, Faculty of Vet. Medicine, Trakia University from 07.01.1987 (assistant professor from 1987 to 1999; Assoc Prof. from 1999 to 2006).

3.) Project leader of 4 research projects (regarding mycotoxic nephropathy in farm animals and humans): CC273 (1992-1995), L414 (1994-1997), CC449 (1994-1997) and CC1003 (2001-2003) funded by National Science Fund of Ministry of Science and Education in Bulgaria:

-project CC273 ("Mycotoxic nephropathy in pigs" - 1992-1995).

-project CC449 (with international participation and title "Clinicomorphological and ultrastructural investigations in mycotoxic nephropathy in poultry" - 1994-1997)

-project L414 (with international participation of scientists from 4 countries and title "Toxicological, clinicomorphological and ultrastructural investigations, diagnostical methods, prophylactic, hygienic and preventive measures in ochratoxicosis in animals with a view to the public health" - 1994-1997). The toxic, teratogenic and carcinogenic effects of OTA- and/or penicillic acid-contaminated feed on mice (100 mice), rats (80 rats) and chickens (100 chickens) and pigs (18 pigs) were studied during 2 years period in addition to mycotoxin-induced pathomorphological and ultrastructural changes in various internal organs. Protective effects of some feed additives against the toxic effects of OTA were studied in rats and chicks as well as some preventive measures and risk evaluation were recommended as high effective to prevent human/animal exposure to OTA.

-project CC1003 (“Experimental investigations on immunosuppressive effect of OTA in pigs” – 2001-2003).


International Experience (country, institution, duration, year):

1.) Bulgarian project leader of Joint Research Project between Bulgaria and UK funded by The Royal Society - London (Joint Project Grant - Reg. Ch. No 207043, Ref. FSU/CEE/JP) and titled: “Fungal nephrotoxins in porcine renal disease in Bulgaria” (1997-2000) – the aim of the project was to clarify the cause of spontaneous porcine and chick nephropathies in Bulgaria

2.) The main Pathologist in eight (8) Joint International Research Projects between Bulgaria and Germany (IPSS D032, E008, E009, E0010, E011, F003, F006, F031) funded by International Pharmaceutical Strategies and Solutions (IPSS) GmbH – Germany (2005-2007) and titled “Clinical animal study on the pharmacokinetics of various chemical compounds following external beam irradiation in rats” (IPSS D032 – 2004-2005), “A clinical study in rats and rabbits on the pharmacokinetics and bioaccumulation of platinum derivatives following the single dose of formulations from PT-1 to PT-13” (IPSS E008, E009, E0010, E011 – 2005-2006), “A clinical study in rats on the pharmacokinetics and bioaccumulation of platinum complexes following the repeated dose over 7 consecutive days of formulations from PT-1 to PT-13 without non-treatment period” (IPSS E008, E009, E0010, E011 – 2005-2007), “Study in rats to determine platinum compound pharmacokinetics” (IPSS E0010, E011 – 2005-2006), “Cold mass-balance study in rats to determine distribution of platinum compound” (IPSS E009 – 2005-2006), “Pharmacokinetics, Toxicokinetics and Tissue Accumulation using the Active Ingredients of Trisenox & KML001 following oral and intravenous administration” (IPSS F003 - 2006), “Investigation of the Pathohistology/Morphology following Repeated Dose of Intravenous NaAsO2 and NaAsO2 Encapsulated in Siosomes®” (IPSS F006 – 2006-2007), “A clinical Study in Rats on the Tissue Distribution, Bioaccumulation and Pharmacokinetics in tissues following Single Dose oral administration of CIS-OXOPLATIN with pilot dose finding study” (IPSS F031 – 2006-2007). The aim of the first project was to evaluate the protective effect of some chemical compounds on pathomorphological changes in various internal organs in rats provoked by external beam irradiation. The aim of the other seven projects was to evaluate pathomorphological changes in various tissues, glands and internal organs in more than 500 rats and 100 rabits provoked by various pharmaceutical compounds as well as pharmacokinetics, toxicokinetics, tissue distribution and bioaccumulation of the same compounds following oral and intravenous administration. The pathomorphological changes in stomach, small and large intestine, caecum, urinary bladder, kidneys, liver, heart, lungs, spleen, lymph nodes, brain, cerebellum, bone marrow, muscle, pancreas, thymus, thyroid gland, adrenal glands, pituitary gland, lachrymal glands, salivary glands, prostate, testicles, loose or reticular connective tissue and skin were evaluated.

3.) A specialisation in Imperial College of Science, Technology and Medicine - London, U.K (2 weeks in September, 1998) – it addressed receiving a first hand knowledge about the methodology of producing a high quantity of mycotoxin OTA necessary for experimental induction of mycotoxic nephropathy in various animals.

4.) A specialisation in Laboratoire de Toxicologie et Sеcurity Alimentaire, Toulouse, France, (4 months in 2000 - NATO grant) - it addressed some genotoxic investigations on tissue samples from spontaneous and experimental cases of mycotoxic nephropathies in various animals.

5.) Marie Curie Outgoing International Fellowship (6th Framework of EU) for 2 years (2007-2008) in University of Johannesburg (Food, Environment and Health Research Group, Faculty of Health Science) and 1 year in Trakia University (Bulgaria), which is the first Marie Curie fellowship in S. Africa funded by European Community and titled: “An expected multicausal nature of spontaneous animal and human nephropathy in Bulgaria and South Africa” - project 18674 “Cause Kidney Damage” (see http://www.esastap.org.za/esastap/stories/stoev.php). The project has addressed the cause of porcine/chicken/human nephropathies in Bulgaria and human nephropathy in South Africa, which are morphologically different in detail and much more prevalent than those seen in Denmark, where their first classical description was made. The same nephropathies can only partly be attributed to ochratoxin A (OTA) as their incidence in Bulgaria is higher, possibly by one to two orders of magnitude, than it was in Danish pigs in the 1960s and 70s, but the average concentrations of OTA in Bulgarian feeds for pigs/chickens (100-200 ppb) were substantially lower than the 1-2 ppm required to reproduce the classical Danish porcine/chicken nephropathy of a similar severity. It seems, therefore, that Bulgarian nephropathy may have a multitoxic aetiology because it cannot be explained by the concentration of OTA alone. Hence a possible synergistic effect between OTA and other mycotoxins is anticipated as was recently proved. New skills acquired in field of: multi-mycotoxin screen, rapid screening methods such as immunoaffinity clean up/fluorimetry, ELISA based immunoassay or cell culture based, cytotoxicity testing (MTT bioassay), enzyme immuno-assays on small columns or membranes, PCR (polymerise chain reaction) analysis including DNA extraction, PCR amplification, purification of PCR product, product quantification and DNA sequence; overview on a large number of up-to-date methods in the field of toxicological characterization of food and feed and establishment of toxinogenic potential of fungi. The fellowship was selected as one of the seven success stories in the Worldwide Research featured in the publication of European Commission’s Marie Curie team highlighting the most successful Marie Curie fellows (see pp 264-267: http://ec.europa.eu/research/mariecurieactions/docs/inspiring_researchers_en.pdf and also pp 104-105 of eStrategies Projects: http://viewer.zmags.com/publication/b802e4ab#/b802e4ab/106).

6) A specialization in field of multi-mycotoxin screen and extraction from various feed or biological (serum, tissue) samples, rapid screening methods such as immunoaffinity clean up (VICAM immuno affinity column chromatography), enzyme immuno-assays on small columns or membranes, ELISA based immunoassay or cell culture based as well as traditional methods for mycotoxin detection as TLC, HPLC, which is performed in Food, Environment and Health Research Group, Faculty of Health Science, University of Johannesburg (2 years - 2007-2008)

7) A specialization in Fungal screening and identification from feed samples as fungal isolation on potato dextrose agar (PDA) and Ohio agricultural and experimental station agar (OAEA), sub-culturing on PDA, malt extract agar (MEA) and czapex yeast extract agar (CYA), macro- and microscopic identification of fungi, establishment of toxinogenic potential of fungi via sub-culturing on YES agar and using TLC – performed in Food, Environment and Health Research Group, Faculty of Health Science, University of Johannesburg (2 years - 2007-2008).

8) A specialization in MTT bioassay (cytotoxicity testing) - performed in Cytotoxic Laboratory, Faculty of Health Science, University of Johannesburg (2 months in 2007)

9) A specialization in field of PCR (polymerise chain reaction) analysis of fungal species (freeze dried or fresh) including DNA extraction, PCR amplification, purification of PCR product, product quantification and DNA sequence - performed in Inqaba Biotec, Pretoria, South Africa (2 weeks in March, 2008).

10) Good skills and experience in supervising PhD students from different countries (international students).

11) Good management skills – have been a manager of lots of people and international research projects.


Invited recent lectures and seminars:

-Invitation to give a talk in a meeting with Director and Deputies Directors of Strategic Partnership and International Resources of SA Department of Science and Technology, Pretoria and the Manager Science and Technology Agreements Fund of National Research Foundation in South Africa (29.01.2007)

-Invitation to give a presentation for the Marie Curie instruments used to reach scientific goals of researchers in Information session on FP7 and the European-South African Science and Technology Advancement Programme (ESASTAP) in University of Johannesburg on 13.04.2007

-Invited lectures/seminars on “Mycotoxic nephropathy in farm animals and humans – preventive measures and risk assessment” in Faculty of Health Science, University of Johannesburg (04.05.2007 and 18.11.2009)

-Invitation to Open Vet Africa 2007 Congress by The Board of Trustees of Animal Aid for Africa (AAA) with Opening Speech and talk with title Food Safety and some foodborne mycotoxicoses” (27.07.2007 in Johannesburg).

-Invitation to give a seminar/lecture in the Onderstepoort Veterinary Institute in Pretoria (14.04.2008) on the topic “Complex aetiology and pathology of mycotoxic nephropathy in Bulgarian pigs and chicks”.



-Invitation to give seminars/lectures in Kaposvar University in Hungary (22-29.06.2010) on the topic “Mycotoxic nephropathy in Bulgarian and S. African pigs: complex etiology and similarity with Balkan Endemic Nephropathy”
Main Fields of Scientific Research (keywords): toxicology, intoxications, pathology, pathomorphology, ultrastructure, mycotoxic nephropathy, ochratoxicosis, Balkan endemic nephropathy (BEN), mycotoxins, ochratoxin A (OTA), penicillic acid (PA), citrinin, fumonisin B1, synergism, heavy metals, cadmium, lead, mercury, animal health, feed additives, protective effect, multi-mycotoxin screen, fungal screening, MTT bioassay, cytotoxicity, PCR analysis, DNA sequence, environmental health, food safety
Foreign Languages (level of proficiency): English – well; Russian – well; Bulgarian - native
VIP Number: 30016596
Membership in Scientific and Professional Institutions, Bodies and Organizations; Scientific awards:

  1. Full member in “International Society on Toxinology” (2002).

  2. Member in “Euroscience Association” (2008), Membership ID: ES03199

  3. Member in “Science Advisory Board” (2006) – Membership ID: 78026 (see the website: http://www.scienceboard.net/forum/pop_profile.asp?mode=display&id=78026)

  4. Member in “Research Board of Advisors” of the American Biographical Institute (2004).

  5. Editorial Board Member of “The Open Toxinology Journal” (2008) (http://bentham.org/open/totnj/EBM.htm)

  6. Editorial Board Member of “ISRN Veterinary Science” (2010) of International Scholarly/Research Network http://www.hindawi.com/isrn/vs/editors.html

  7. Reviewer/member in International Reviewers Panel of many peer reviewed international journals as “Medical Science Monitor”, “Toxicology”, “Research in Veterinary science”, “Avian Pathology”, “Food and Chemical Toxicology”, “Archives of Industrial Hygiene and Toxicology”, etc.

  8. Included in the 4th (2002-2003), 5th (2004-2005) and 6th (2006-2007) Editions of ”Who’s Who in Medicine and Healthcare” - VIP Number: 30016596

  9. Included in the 7th (2003-2004), 8th (2005-2006), 9th (2006-2007), 10th (2008-2009) and 11th (2011-2012) Editions of “Who’s Who in Science and Engineering” - VIP Number: 30016596

  10. Included in the 61st edition of “Who’s Who in America” (2007) – VIP Number: 30016596

  11. Included in the 21st (2004) and 22nd (2009) editions of “Who’s Who in the World” – VIP Number: 30016596

  12. Included in “2000 Outstanding Scientists of the 21st Century” (2004) and “Outstanding Scientists of the 21st Century - Inaugural Edition” (2007) for outstanding contribution in field of “Toxicologic Pathology”, and invited to be included in the “Honours List” and “Dedication Edition” of the same issue, published, signed and sealed by the headquarters of International Biographical Center (IBC), Cambridge, England

  13. Included in “2000 Outstanding Scientists 2008/2009”, published by International Biographical Center (IBC), Cambridge, England.

  14. Included in “Great Minds of the 21st Century – 2004/2005, 2005/2006 and 2007/2008 Editions” for significant accomplishment within and mastery of “Toxicologic Pathology”, and invited to be included in the “Dedication Section” of the same issues, published and signed by the Governing Board of Editors of American Biographical Institute (ABI).

  15. Included in “2000 Outstanding Intellectuals of the 21st Century“ (2005, 2007 and 2008), published by IBC, Cambridge.

  16. Included in Inaugural Edition of “International Profiles of Accomplished Leaders” (2010), published by ABI

  17. Included in the World Premier Edition of “International Directory of Experts and Expertise”, published by ABI.

  18. Accepted for inclusion in the issue “500 Greatest Geniuses of the 21st Century”, publication of ABI, which includes the biography of 500 greatest living geniuses and most prominent thinkers of our time.

  19. Included in “International Biographical Centre Awards Roster of 2004”, published by IBC, Cambridge.

  20. Included in “The World Book of Knowledge – 2005 Edition”, A Global Compendium of 500 Eminent Leaders, Thinkers, Innovators, Experts, and Persons of Influence in World Markets and Organizations, published by ABI.

  21. Included in the “Cambridge Blue Book – 2004-2007” – the authoritative and genuine reference of achievement and Nominated as a “Laureate of the Cambridge Blue Book” and “The Cambridge blue book man of the year” by IBC, Cambridge, England. Person Ref.: 90667. Entry Ref: 63731 (2004) and 69639 (2006)

  22. Inducted into “American Hall of Fame for Distinguished Accomplishments in Toxicologic Pathology” (2009) authorized by American Biographical Institute.

  23. Selected as one of the IBC’s Top 100 Scientists and included in “IBC Top 100 Scientists – 2005”, ratified by Awards Board of International Biographical Centre, Cambridge, England.

  24. Selected as one of the Leading Scientists of the World and included in “IBC Leading Scientists of the World – 2005, 2006 and 2008”, ratified by Awards Board of International Biographical Centre, Cambridge, England.

  25. Selected to be a recipient of “The Excellence Award” by the Recognition Board of IBC, Cambridge (2006)

  26. Selected to be a recipient of “The Archimedes Award” by the Recognition Board of IBC, Cambridge (2006)

  27. Selected to be a recipient of prestigious “Pinnacle of Achievement Award” by ABI (2010)

  28. Selected to be a “Research Fellow” of ABI for contributions to the global research (2005) and nominated for ABI Fellow (2010)

  29. Selected to be included in the World Record for Achievements as the “World Record Holder” by The World Record Council of Research (2007)

  30. Honored with “The Decree of Excellence” by the Award Board of International Biographical Centre, Cambridge (2005)

  31. Accepted for “IBC Lifetime Achievement Award” of International Biographical Centre, Cambridge (2004)

  32. Approved for “21st Century Award for Achievement” in recognition of outstanding contribution by the Editorial Board of International Biographical Centre, Cambridge, England (2005)

  33. Named as a candidate for a “Master Diploma with Honors” from the “World Academy of Letters” in U.S.A. – given for excellent background of achievement (2005 and 2008).

  34. Nominated for “Noble Laureate 2004 by the Governing Board of Editors of American Biographical Institute.

  35. Nominated to receive “Gold Medal for Bulgaria” by ABI (2006, 2007, 2009, 2010)

  36. Nominated for inclusion in “500 Great Leaders – Honors Edition”, published by IBC, Cambridge (2009).

  37. Nominated for inclusion in “500 Great Leaders”, published by ABI (2010).

  38. Nominated for “ABI Genius Laureate of Bulgaria” by ABI (2006)

  39. Nominated to be one of the 100 honored recipients of the prestigious “American Medal of Honor” by the Governing Board of Editors of American Biographical Institute.

  40. Nominated for “Most Notable Intellectual of 2008” by the Nominating Committee of American Biographical Institute (2009)

  41. Nominated for “Man of the year” for 2004, 2005, 2006, 2007, 2008 and 2010 by American Biographical Institute and included in the issue “Man of the year 1990-2006 – A celebrated Collection of Biographies”.

  42. Nominated for “Man of the Year Commemorative Medal” (2005, 2006 and 2008) by American Biographical Institute.

  43. Nominated for “Man of Achievement - 2005” by American Biographical Institute.

  44. Nominated for “2007 Man of Science Award” and “Man of the year in Science” (2008 and 2009) by American Biographical Institute.

  45. Nominated for “Year 2004 Universal Award of Accomplishment” of American Biographical Institute.

  46. Nominated for “World Lifetime Achievement Award” of American Biographical Institute (2004 and 2007).

  47. Nominated for “Lifetime Achievement Award” of the United Cultural Convention (2005, 2006)

  48. Nominated for Lifetime Achievement Award of The World Congress of Arts, Sciences and Communications.

  49. Nominated to be a recipient of the “Legion of Honor of the United Cultural Convention” for outstanding achievement (2010).

  50. Nominated for “Top 100 Scientists Pinnacle of Achievement Award” by Awards Board of IBC, Cambridge.

  51. Nominated for “IBC Living Science Award” of International Biographical Centre, Cambridge, England (2004)

  52. Nominated as a Laureate of the “Da Vinci Diamond” by International Biographical Centre, Cambridge (2004 and 2006).

  53. Nominated for “International Scientist of the year 2004” and “International Educator of the year 2004” by International Biographical Centre, Cambridge, England.

  54. Nominated for “International Biographical Association Scientist of the year” for 2006, Cambridge, England.

  55. Nominated for “International professional of the year 2005” by the Award Board of IBC, Cambridge (2005)

  56. Nominated for “International health professional of the year” by the Award Board of IBC, Cambridge (2005 and 2007)

  57. Nominated for “Presidential Seal of Honor 2005” by the Board of Directors of American Biographical Institute.

  58. Nominated for “The World Medal of Freedom” by American Biographical Institute (2007, 2009).

  59. Nominated for “International Peace Prize” by the United Cultural Convention of the U.S.A (2004, 2005, 2006, 2009, 2010).

  60. Invited to become an “Academician” of the American Biographical Institute (2010).

  61. Invited to receive “The Seat of Wisdom” as one of the Great Minds of 21st Century by ABI (2010).

  62. Invited to be included into the “IBC Hall of Fame” authorized by IBC, Cambridge (2004).

  63. Invited to be included in “Living Legends – 2004”, “The First Five Hundred - 2004”, and “The Lifetime of Achievement One Hundred – 2005”, published by International Biographical Centre, Cambridge, England.

  64. Invited to be included in “The International Register of Profiles – 13th Edition”, an historical document recording the biographical testaments of the world’s foremost individuals, published by International Biographical Centre, Cambridge, England (2005).

  65. Invited to be an Ambassador to the Inaugural World Forum at Oxford University in July 2006 and to the World Forum at Washington DC in July 2007 by IBC, Cambridge and ABI.

  66. Invited to be a Deputy Director General for Europe of the International Biographical Centre, Cambridge, England (2004).

  67. Invited to become a Hon. Director General for Europe of the International Biographical Centre, Cambridge, England (2006).

  68. Invited to be included into “The Contemporary Elite” – a special frontispiece section of “The Contemporary Who’s Who of Professionals”, published by American Biographical Institute (2005).

  69. Invited to be a member of “ABI Research Association’s Board of Governors” (2004), “The Order of International Ambassadors (2006, 2010)” and “Sovereign Ambassador of The Order of American Ambassadors” (2006), “Order of International Merit” (2008, 2010) and “American Order of Merit” of ABI representing Bulgaria (2009).

  70. Invited to be a member of “The World Peace and Diplomacy Forum”, “The Order of International Fellowship”, “Order of International Merit” (2008) and “The Order of Distinction” by International Biographical Centre, Cambridge, England (2004).

  71. Award for “Most successfully accomplished scholar in abroad” given by the Rector of Trakia University in occasion of 35 years high education in Stara Zagora, Bulgaria (2009).


The addresses of scientists and collaborators who work in the same area and would be able to give an independent and authoritative referee statements about me:

1.) Prof. Mike Dutton, PhD, DSc, Senior Research Fellow (Director, Food, Envirnoment & Health Research group of Faculty of Health Sciences, University of Johannesburg), PO Box 17011 Doornfontein, 2028 Gauteng, South Africa, Tel: (+27)(11)559-6374, Fax: (+27)(11)559-6227, Cell: 083-459-3314, E-mail: mdutton@uj.ac.za

2.) Dr. Maja Peraica, PhD / Dr. Bozica Radic, Dr.Sc., Institute for Medical Research and Occupational Health, University of Zagreb, 2 Ksaverska cesta, PO Box 291, HR-41001 Zagreb, Croatia, Tel.: (+385 1) 4673-188, Fax: (+385 1) 4673-303, E-mail: mperaica@imi.hr

3.) Prof. Stefan Denev, PhD, DSc, Department of Microbiology, Faculty of Agriculture, Trakia University, Students campus, 6000 Stara Zagora, Bulgaria, A second position: General Manager of Alltech in Bulgaria, Cell: +359888349777, Fax: +359 42601916, E-mail: stefandenev@hotmail.com, E-mail: sdenev@alltech.com

4.) Emeritus Prof. Peter George Mantle, PhD, DSc, Dept. of Microbial Biochemistry, Imperial College of Science Technology and Medicine, London SW7 2AY, UK, E-mail: p.mantle@ic.ac.uk, Tel: 01715945245

5.) Prof. Edmond Ekue Creppy, PhD, DSc, Laboratoire de Toxicologie et d'Hygiene Appliquee, U.F.R. des Sciences Pharmaceutiques, University Victor Segalen, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France, Tel: 05 57 571217, Fax: 05 56 986685, E-mail: sec.tox@tox.u-bordeaux2.fr

6.) Dr. Isabelle P. Oswald, PhD, Laboratoire de Pharmacologie-Toxicologie, INRA, 180 Chemin de Tournefeuille, BP 3, 31931 Toulouse cedex 09, France, Tel : 33 (0) 5 61 28 54 80, Fax : 33 (0) 5 61 28 53 10, E-mail: ioswald@toulouse.inra.fr

7.) Prof. Benedicte Hald, PhD, Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, 13 Bülowsvej, DK-1870 Frederiksberg C, Denmark, Tel: +45 35 28 27 60; Fax: +45 35 28 27 57; E-mail: VETMI@KVL.DK




The most recent recognitions/certificate from IBC and ABI in addition to some of the Who’s Who publications are enclosed in order to certify the accomplishment of the researcher in the field of “Veterinary Pathology”:















Prof. Stoycho Stoev became a registered member of The Science Advisory Board on Tuesday, October 24, 2006
Membership Number: 78026









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