Advanced ovarian cancer as a risks of primary multiple malignant tumors after the treatment of extra genital cancer
FERTILITY SPARING TREATMENT FOR GYNECOLOGICAL CANCER
Изтегляне 1.05 Mb.
|
FERTILITY SPARING TREATMENT FOR GYNECOLOGICAL CANCERGALINA CHAKALOVAInt. J. Gynecol. Cancer, vol. 21, Suppl 3, October 2011, p.1267.National Oncology Hospital, Sofia, Bulgaria Background and aims: To explore the outcome and long-term follow-up of fertility sparing surgery for gynecological cancer. Methods:A prospective study between 1987 and 2010 of all women with stage IA ovarian cancer and stage I cervical cancer, treated with fertility sparing surgery. All patients were between 19 and 35 years of age and desired future fertility. Results: Forty-two women with stage IA (36 with Stage IA1 and 6 with Stage IA2) carcinoma of the cervix were treated with conization. The tumors had squamous (86%) and adenocarcinoma (14%) histology. Fourteen women with stage IA ovarian low malignant potential (LMP) tumors underwent unilateral salpingo-ophorectomy with contralateral biopsy and omentectomy. Most tumors had serous (50%) or mucinous (33%) histology. In 2 cases (17%) histologically disgerminom was detected. No patients received adjuvant therapy. Between 6 and 34 months after the treatment, the patients became pregnant. In 41 cases, patients gave birth to 1 baby and in 11 cases – to 2 babies. The second childbirth appeared 2 to 5 years after the fist one. None of the women have developed recurrent disease after a median follow-up of 148 months. The follow-ups were performed with gynecological exams, cytology, ultrasound and tumor markers. Conclusion: Women with cervical carcinoma and negative margins may be treated with conservative, fertility sparing surgery (conization). Fertility-sparing surgery for stage IA ovarian LMP tumors is possible, and risk of the recurrences is minimal. Multiple primary tumors in Bulgarian women following breast cancer, 1993-2010. Gavrilov, I.,N. Dimitrova, G. Chakalova. Int. J. Gynecol. Cancer, vol. 23, Suppl 1, 2013, p.44. GYNECOLOGICAL CANCER INCIDENCE AND SURVIVAL IN BULGARIA FOR PAST 20 YEARS G. Chakalova, N. Dimitrova Background: In Bulgaria, there are over 3300 diagnosed with gynecological cancer annually. The aim of the study was to estimate the incidence, mortality and survival for the past 20 years. Materials and methods: Gynecological cancer in Bulgaria during the period 1993-2009 according data from Bulgarian National Cancer Registry were analyzed. Age-standardized incidence and mortality rates per 100 000 persons were estimated by Joinpoint regression. Life table method for gynecological cancer survival was used. Results: Cervical cancer incidence was increased from 795 in 1993, to 1072 in 2009, with age- standardized rates from 14,0 in 1993 to 18,7 in 2009 per 100 000. The mortality was increased from 4,8 to 5,4 per 100 000. Endometrial cancer incidence was increased from 943 to 1278, with age- standardized rates from 13,8 to 17,3 per 100 000. The mortality was increased from 2,4 to 2,9 per 100 000. Ovary cancer incidence was increased from 657 to 862, with age- standardized rates from 10,6 to 13,0 per 100 000. The mortality was increased from 4,6 to 5,2 per 100 000. Survival for all sates was increased: from 49,7% to 54,5% for cervical cancer, from 66,6% to 69,0% for endometrial cancer, and from 35,4% to 40,3% for ovary cancer. Conclusion: Our results indicated the difference between gynecological cancer incidence and mortality in Bulgaria and other European countries. The economic problems and health politic in Bulgaria are the most important cause of absence the early detection and adequate treatment of the gynecological cancer. High-risk human papillomavirus infection is associated with obesity T. Taseva*, G. Chakalova **, J. Genova*** Eur. J. Gynecol. Oncol., 2, XXXIV, 2013, 117-120. Institute of Genetics „Acad. D. Kostoff”, Department of Molecular Genetics*, Department of Gynecological Oncology, National Oncologic Hospital and Medical Center Gineka**, Genetic medico-diagnostic laboratory Genica***, Sofia, Bulgaria
Каталог: assets -> files -> Nauka-SDO Nauka-SDO -> Конкурс за заемане на академична длъжност „Професор по научната специалност Nauka-SDO -> На избрани нерецензирани научни трудове Nauka-SDO -> Списък публикации Nauka-SDO -> Специализирана болница за активно лечение по онкология-еад Nauka-SDO -> Рецензия от проф. Д-р н. Гаврилова дм Изтегляне 1.05 Mb. Сподели с приятели:
|