Нови субстанции в преработените храни
Изтегляне 136.32 Kb.
|
- Навигация на страницата:
- Какво можете да направите
ДобавкиПреработката на храните се използва предимно за да бъде направено годно за ядене това, което не е ядливо. Добавките се използват най-вече за по-голяма трайност на фалшивата храна и за да ви накарат да ядете повече. Вкусовите подобрители са предимно концентриран протеин, пълен с много бета-карболини, водещи до физическо пристрастяване и каращи ви да ядете повече. Глутаматът (популярен в китайската кухня) индиректно влияе на същите (бензодиазепиновите) рецептори.
Какво можете да направите?Консумирайте колкото е възможно по-малко преработена храна, особено купешка преработена протеинова храна. Яжте възможно повече плодове, някои пресни сурови животински храни (като сашими) редовно, и други „храни за мозъка”. (виж предложенията за диета). Източници
Абстракти на повечето материали могат да се намерят в Националната библиотека по медицина (http://www.ncbi.nlm.nih.gov/pubmed) (1) Loscher, W. et al, Withdrawal precipation by benzodiazepine receptor antagonists in dogs chronically treated with diazepam or the novel anxiolytic and anticonvulsant beta-carboline abecarnil. Naunyn Schmiedebergs Arch. Pharmacol. 1992 / 345 (4) / 452-460. , De Boer, S.F. et al, Common mechanisms underlying the proconflict effects of corticotropin, a benzodiazepine inverse agonist and electric foot shock. J. Pharmacol. Exp. Ther. 1992 / 262 (1) / 335-342. , Little, H.J. et al, The benzodiazepines : anxiolytic and withdrawal effects. Neuropeptides 1991 / 19 / suppl. 11-14. , Eisenberg, R.M. et al, Effects of beta-carboline-ethyl ester on plasma corticosterone -- a parallel with antagonist-precipated diazepam withdrawal. Life Sci. 1989 / 44 (20) / 1457-1466. , Maiewski, S.F. et al, Evidence that a benzodiazepine receptor mechanism regulates the secretion of pituitary beta-endorphin in rats. Endocrinology 1985 / 117 (2) / 474-480. (2) (no author listed) Tetrahydro-beta-carbolines in foodstuffs, urine, and milk : physiological implications. Nutr. Rev. 1991 / 49 (12) / 367-368. (3) Papavergou, E. et al, Tetrahydro-beta-carboline-carboxylic acids in smoked foods. Food Addit. Contam. 1992 / 9 (1) / 83-95. (5) Rommelspacher, H. et al, Is there a correlation between the concentration of beta-carbolines and their pharmacolodynamic effects ? Prog. Clin. Biol. Res. 1982 / 90 / 41-55. (6) Airaksinen, M.M. et al, Affinity of beta-carboline on rat brain benzodiazepine and opiate binding sites. Med. Biol. 1980 / 58 (6) / 341-344. (7) Wakabayashi, K. et al, Recently identified nitrite-reactive compounds in food : occurence and biological properties of the nitrosated products. IARC Sci. Publ. 1987 / 84 / 287-291. (8) Jolivette, L.J. et al, Thietanium ion formation from the food mutagen 2-chloro-4-(methylthio)butanoic acid. Chem. Res. Toxicol. 1998 / 11 (7) / 794-799. (9) Sugimura, T. et al, Carcinogenic, Mutagenic, and Comutagenic Aromatic Amines in Human Foods. Natl. Cancer Inst. Monogr. 1981 / 58 / 27-33. (10) Overvik, E. et al, Influence of creatine, amino acids and water on the formation of the mutagenic heterocyclic amines found in cooked meat. Carcinogenesis 1989 / 10 (12) / 1293-1301. , Yoshida, D. et al, Formation of mutagens by heating foods and model systems. Environ. Health. Perspect. 1986 / 67 / 55-58. (11) Solyakov, A. et al, Heterocyclic amines in process flavours, process flavour ingredients, bouillon concentrates and a pan residue. Food Chem. Toxicol. 1999 / 37 (1) / 1-11. , Skog, K. et al, Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectometry. J. Chromatogr. A. 1998 / 803 (1-2) / 227-233. , Stavric, B. et al, Mutagenic heterocyclic aromatic amines (HAA's) in 'processed food flavour' samples. Food Chem. Toxicol. 1997 / 35 (2) / 185-197. , Wakabayashi, K. et al, Human exposure to mutagenic / carcinogenic heterocyclic amines and comutagenic beta-carbolines. Mutat. Res. 1997 / 376 (1-2) / 253-259. , Galceran, M.T. et al, Determination of heterocyclic amines by pneumatically assisted electrospray liquid chromatography-mass spectometry. J. Chromatogr. A. 1996 / 730 (1-2) / 185-194. , Gross, G.A. et al, Heterocyclic aromatic amine formation in grilled bacon, beef and fish and in grilled scrapings. Carcinogenesis 1993 / 14 (11) / 2313-2318. , Sugimura, T. et al, Mutagenic factors in cooked foods. Crit. Rev. Toxicol. 1979 / 6 (3) / 189-209. (12) Rommelspacher, H. et al, beta-Carbolines and tetrahydroisoquinolines : detection and function in mammals. Planta. Med. 1991 / 57 (7) / 585-592. , Pawlik, M. et al, Quantitative autoradiograph of (3H)norharman ((3H)beta-carboline) binding sites in the rat brain. J. Chem. Neuroanal. 1990 / 3 (1) / 19-24. , Rommelspacher, H. et al, Harman induces preference for ethanol in rats : is the effect specific for ethanol ? Parhmacol. Biochem. Behav. 1987 / 26 (4) / 749-755. , Rommelspacher, H. et al, Benzodiazepine antagonism by harmane and other beta-carbolines in vitro and in vivo. Eur. J. Pharmacol. 1981 / 70 (3) / 409-416. (13) Totsuka, Y. et al, Structural determination of a mutagenic aminophenylnorharman produced by the co-mutagen norharman with aniline. Carcinogenesis 1998 / 19 (11) / 1995-2000. , Skog, K. et al, Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectometry. J. Chromatogr. A. 1998 / 803 (1-2) / 227-233. (14) Vikse, R. et al, Heterocyclic amines in cooked meat. (in Norwegian) Tidsskr. Nor. Laegeforen. 1999 / 119 (1) / 45-49. , Sinha, R. et al, Heterocyclic amine content of pork products cooked by different methods and to varying degrees of doneness. Food Chem. Toxicol. 1998 / 36 (4) / 289-297. , Byrne ,C. et al, Predictors of heterocyclic amines intake in three prospective cohorts. Cancer Epidemiol. Biomarkers 1998 / 7 (6) / 523-529. , Kaplan, S. et al, Nutritional factors in the etiology of brain tumors : potential role of nitrosamines, fat, and cholesterol. Am. J. Epidemiol. 1997 / 146 (10) / 832-841. , Ward, M.H. et al, Risk of adenocarcinoma of the stomach and esophagus with meat cooking method and doneness preference. Int. J. Cancer 1997 / 71 (1) / 14-19. , La Vecchia, C. et al, Selected micronutrient intake and the risk of gastric cancer. Cancer Epidemiol. Biomarkers Prev. 1994 / 3 (5) / 393-398. , Buiatti, E. et al, A case-control study of gastric cancer and diet in Italy : II. Association with nutrients. Int. J. Cancer 1990 / 45 (5) / 896-901. , Proliac, A. et al, Isolation and identification of two beta-carbolins in roasted chicory root. Helv. Chim. Acta 1976 / 59 (7) / 2503-2507. (in french) (15) Salmon, C.P. et al, Effects of marinating on heterocyclic amine carcinogen formation in grilled chicken. Food Chem. Toxicol. 1997 / 35 (5) / 433-441. , Shibata, A. et al, Dietary beta-carotene, sigarette smoking and lung cancer in men. Cancer Causes Control 1992 / 3 (3) / 207-214. (16) Chiu, C.P. et al, Formation of heterocyclic amines in cooked chicken legs. J. Food Prot. 1998 / 61 (6) / 712-719. , Byrne, C. et al, Predictors of dietary heterocyclic amine intake in three prospective cohorts. Cancer Epidemiol. Biomarkers Prev. 1998 / 7 (6) / 523-529. , Wakabayashi, K. et al, Human exposure to mutagenic / carcinogenic heterocyclic amines and co-mutagenic beta-carbolines. Mutat. Res. 1997 / 376 (1-2) / 253-259. , Salmon, C.P. et al, Effects of marinating on heterocyclic amine carcinogen formation in grilled chicken. Food Chem Toxicol. 1997 / 35 (5) / 433-441. , Skog, K. et al, Polar and non-polar heterocyclic amines in cooked fish and meat products and their corresponding pan residues. Food Chem. Toxicol. 1997 / 35 (6) / 555-565. , Pfau, W. et al, Characterization of the major DNA adduct formed by the food mutagen 2-amino-3-methyl-9H-pyrido(2,3-b)indole (MeAalphaC) in primary rat hepatocytes. Carcinogenesis 1996 / 17 (12) / 2727-2732. , Thiebaud, H.P. et al, Airborne mutagens produced by frying beef, pork and soy-based food. Food and Chemical Toxicology 1995 / 10 / 821-828. , Ohgaki, H. et al, Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysates. Carcinogenesis. 1984 / 5 (6) / 815-819. , Tomita, I. et al, Mutagenicity of various Japanese foodstuffs treated with nitrite. II. Directly acting mutagens produced from N-containing compounds in foodstuffs. IARC Sci. Publ. 1984 / 57 / 33-41. (17) Knize, M.G. et al, Characterization of mutagenic activity in cooked-grain-food products. Food Chem. Toxicol. 1994 / 32 (1) / 15-21. (18) Ozawa, Y. et al, Occurence of stereoisomers of 1-(2'-pyrrolidinethione-3'-yl)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid in fermented radish roots and their different mutagenic properties. Biosci. Biotechnol. Biochem. 1999 / 63 (1) / 216-219. , Sen, N.P. et al, Analytical methods for the determination and mass spectometric confirmation of 1-methyl-2-nitroso-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid and 2-nitroso-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid in foods. Food. Addit. Contam. 1991 / 8 (3) / 275-289. , Sugimura, T. et al, Mutagenic factors in cooked foods. Crit. Rev. Toxicol. 1979 / 6 (3) / 189-209. (19) Herraiz, T. et al, Presence of tetrahydro-beta-carboline-3-carboxylic acids in foods by gas chromatography-mass spectometry as their N-methoxycarbonylmethyl ester derivates. J. Chromatogr. A. 1997 / 765 (2) / 265-277. (20) Skog, K.I. et al, Carcinogenic heterocyclic amines in model systems and cooked foods : a revieuw on formation, occurence and intake. Food Chem. Toxicol. 1998 / 36 (9-10) / 879-896. (21) Kurosaka, R. et al, Detection of 2-amino-1-methyl-6-(4-hydroxyphenyl)imidazo(4,5-b) pyridine (4'-OH-PhIP) level comparable to PhIP. Jpn. J. Cancer Res. 1992 / 83 (9) / 919-922. (22) Okogoni, H. et al, Induction of aberrent cryptfoci in C57BL/6N mice by 2-amino-9H-pyrido(2,3-b)indole (AalphaC) and 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline (MeIQx) Cancer Lett. 1997 / 111 (1-2) / 105-109. , Zhang, X.B. et al, Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice : 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine and amino(alpha)carboline. Carcinogenesis 1996 / 17 (10) / 2259-2265. , Yoo, M.A. et al, Mutagenic potency of heterocyclic amines in the Drosophila wing spot test and its correlation to carcinogenic potency. Jpn. J. Cancer Res. 1985 / 76 (6) / 468-473. (23) Beamand, J.A. et al, Effect of some cooked food mutagens on unscheduled DNA synthesis in cultured precision-cut rat, mouse and human liver slices. Food Chem. Toxicol. 1998 / 36 (6) / 455-466. , Yoshida, D. et al, Formation of mutagens by heating foods and model systems. Environ. Health Perspect. 1986 / 67 / 55-58. , Ohgaki, H. et al, Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysates. Carcinogenesis. 1984 / 5 (6) / 815-819. (24) Pfau, W. et al, Characterization of the major DNA adduct formed by the food mutagen 2-amino-3-methyl-9H-pyrido(2,3-b)indole (MeAalphaC) in primary rat hepatocytes. Carcinogenesis 1996 / 17 (12) / 2727-2732. , Pfau, W. et al, Pancreatic DNA adducts formed in vitro and in vivo by the food mutagens 2-amino-1-methyl-6-phenylimidazo(4,5-b)prydine (PhIP) and 2-amino-3-methyl-9H-pyrido(2,3-b)indole (MeAalphaC). Mutat. Res. 1997 / 378 (1-2) / 13-22. (25) Skog, K. et al, Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectometry. J. Chromatogr. A. 1998 / 803 (1-2) / 227-233. , Galceran, M.T. et al, Determination of heterocyclic amines by pneumatically assisted electrospray liquid chromatography-mass spectometry. J. Chromatogr. A. 1996 / 730 (1-2) / 185-194. , Yamaguchi, K. et al, Presence of 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole in broiled beef. Gann. 1980 / 71 (5) / 745-746. , Yamaizumi, Z. et al, Detection of potent mutagens, Trp-P-1 and Trp-P-2 in broiled fish. Cancer Lett. 1980 / 9 (2) / 75-83. , Sugimura, T. et al, Mutagenic factors in cooked foods. Crit. Rev. Toxicol. 1979 / 6 (3) / 189-209. (26) Ashida, H. et al, Tryptophan pyrolysis products, Trp-P-1 and Trp-P-2 induce apoptosis in primary cultured rat hepatocytes. Biosci. Biotechnol. Biochem. 1998 / 62 (11) / 2283-2287. , Sasaki, Y.F. et al, In vivo genotoxicity of heterocyclic amines detected by a modified alkaline single cell gel electrophoresis assay in a multiple organ study in the mouse. Mutat. Res. 1997 / 395 (1) / 57-73. (27) Sugimura,T. et al, Mutagens in food. Journal of Agriculture and Food Chemistry 1995 / 43 / 404-414. , Manabe, S. et al, Carcinogenic tryptophan pyrolysis products in the environment. J. Toxicol. Sci. 1991 / 16 (suoppl.1) / 63-72. (28) Skog, K. et al, Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectometry. J. Chromatogr. A. 1998 / 803 (1-2) / 227-233. , Galceran, M.T. et al, Determination of heterocyclic amines by pneumatically assisted electrospray liquid chromatography-mass spectometry. J. Chromatogr. A. 1996 / 730 (1-2) / 185-194. , Yamaguchi, K. et al, Presence of 3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole in broiled beef. Gann. 1980 / 71 (5) / 745-746. , Yamaizumi, Z. et al, Detection of potent mutagens, Trp-P-1 and Trp-P-2 in broiled fish. Cancer Lett. 1980 / 9 (2) / 75-83. , Sugimura, T. et al, Mutagenic factors in cooked foods. Crit. Rev. Toxicol. 1979 / 6 (3) / 189-209. (29) Ozawa, Y. et al, Occurence of stereoisomers of 1-(2'-pyrrolidinethione-3'-yl)-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid in fermented radish roots and their different mutagenic properties. Biosci. Biotechnol. Biochem. 1999 / 63 (1) / 216-219. , Lopez-Rodrigeuz, M. et al, Reaction of 6-hydroxy-tetrahydro-beta-carboline-3-carboxylic acids with isocyanates and isothiocyanates. Chem. Pharm. Bull. Tokyo 1994 / 42 (12) / 2108-2112. (30) Sugimura, T. et al, Mutagenic factors in cooked foods. Crit. Rev. Toxicol. 1979 / 6 (3) / 189-209. (31) Burkard, W.P. et al, The benzodiazepine antagonist Ro15-1788 reverses the effect of methyl-beta-carboline-3-carboxylate, but not of harmiline on cerebellar cGMP and motorperformance in mice. Eur. J. Pharmacol. 1985 / 109 (2) / 241-247. (32) Serrano, A. et al, NMDA antagonists block restraint-induced increase in extracellular DOPAC in rat nucleus accumbens. Eur. J. Pharmacol. 1989 / 162 (1) / 157-166. , Claustre, Y. et al, Pharmacological studies on stress-induced increase in frontal cortical dopamine metabolism in the rat. J. Pharmacol. Exp. Ther. 1986 / 238 (2) / 693-700. (33) Holley, L.A. et al, Dissociation between the attentional effects of infusions of a benzodiazepine receptor agonist and inverse agonist into the basal forebrain. Psychopharmacology (Berl.) 1995 / 120 (1) / 99-108. , Shibata, S. et al, Effects of benzodiazepine and GABA antagonists on anticonflict effects of antianxiety drugs injected into the rat amygdala in a water-lick suppression test. Psychopharmacology 1989 / 98 (1) / 38-44. (34) Jones, B.J. et al, Microinjections of methyl-beta-carboline-3-carboxylate into the dorsal raphe nucleus : behavioral consequences. Pharmacol. Biochem. Behav. 1986 / 24 (5) / 1487-1489. (35) Tokuyama, S. et al, Blockade of the development of analgesic tolerance to morphine by psychological stress through benzodiazepine receptor mediated mechanism. Jpn. J. Pharmacol. 1989 / 51 (3) / 425-427. , Kaijima, M. et al, Hypnotic action of ethyl-beta-carboline-3-carboxylate, a benzodiazepine receptor antagonist, in cats. Electroencephalogr. Clin. Neurophysiol. 1984 / 58 (3) / 277-281. (36) Merlo Pick ,E. et al, A two compartment exploratory model to study anxiolytic / anxiogenic effects of drugs in the rat. Pharmacol. Res. 1989 / 21 (5) / 595-602. (37) Chermat, R. et al, Interactions of Ginkgo biloba extract (EGb 761), diazepam and ethyl-beta-carboline-3-carboxylate on social behaviour of the rat. Pharmacol. Biochem. Behav. 1997 / 56 (2) / 333-339. , Maestripieri, D. et al, Anxiety in rhesus monkey infants in relation to interactions with their mother and other social companions. Dev. Psychobiol. 1991 / 24 (8) / 571-581. , Hindley, S.W. et al, The effects of methyl-beta-carboline-3-carboxylate on social interaction microinjected into the nucleus raphe dorsalis of the rat. Br. J. Pharmacol. 1985 / 86 (3) / 753-761. (38) Vellucci, S.V. et al, The effect of midazolam and beta-carboline-3-carboxylate methyl ester on behaviour, steroid hormones and central monoamine metabolites in social groups of talapoin monkeys. Psychopharmacology (Berl.) 86 / 90 (3) / 367-372. (39) Skolnick, P. et al, A novel chemically induced animal model of human anxiety. Psychopathology 1984 / 17 (suppl.1) / 25-26. (40) Insel, T.R. et al, Rearing paradigm in a nonhuman primate affects response to beta-CCE challenge. Psychopharmacology (Berl.) 1988 / 96 (1) / 81-86. , Insel, T.R. et al, A benzodiazepine receptor-mediated model of anxiety studies in nonhuman primates and clinical implications. Arch. Gen. Psychiatry 1984 / 41 (8) / 741-750. , Ninan, P.T. et al, Benzodiazepine-mediated experimental ''anxiety'' in primates. Science 1982 / 218 (4579) / 1332-1334. (41) Murai, T. et al, Opposite effects of midazolam and beta-carboline-3-carboxylic acid-ethyl ester on the release of dopamine from rat nucleus accumbens measured by in vivo microdialysis. Eur. J. Pharmacol. 1994 / 261 (1-2) / 65-71. , Kalin, N.H. et al, Effects of beta-carbolines on fear-related behavioral and neurohormonal responses in infant rhesus monkeys. Biol. Psychiatry. 1992 / 31 (10) / 1008-1019. (42) Naughton, N. et al, A benzodiazepine antagonist inhibits the cerebral metabolic and respiratory depressant effects of fentanyl. Life Sci. 1985 / 36 (23) / 2239-2245. (43) Hoffman, W.E. et al, Cerebrovascular and cerebral metabolic effects of flurazepam and a benzodiazepine antagonist, 3-hydroxymethyl-beta-carboline. Eur. J. Pharmacol. 1984 / 106 (3) / 585-591. , Mendelson, W.B. et al, A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam. Science 1983 / 219 (4583) / 414-416. (44) Ongini, E. et al, Intrinsic and antagonistic effect of beta-carboline FG7142 on behavioral and EEG actions of benzodiazepines and pentobarbital in cats. Eur. J. Pharmacol. 1983 / 95 (1-2) / 125-129. (45) Adamec, R., Modelling anxiety disorder following chemical exposures. Toxicol. Ind. Health. 1994 / 10 (4-5) / 391-420. , Corda, M.G. et al, Long-lasting proconflict effects induced by chronic administration of the beta-carboline derivate FG7142. Neurosci. Lett. 1985 / 62 (2) / 237-240. (46) Agmo, A. et al, Benzodiazepine receptor ligands and sexual behavior in the male rat : the role of GABAergic mechanisms. Pharmacol. Biochem. Behav. 1991 / 38 (4) / 781-788. (47) Fung, S.C. et al, Multiple effects of drugs acting on benzodiazepine receptors. Neurosci. Lett. 1984 / 50 (1-3) / 203-207. (48) Nakane, H. et al, Stress-induced norepinephrine release in the rat prefrontal cortex measured by microdialysis. Am. J. Physiol. 1994 / 267 (6 Pt 2) / R1559-1566. , Ida, Y. et al, Anxiogenic beta-carboline FG7142 produces activity of neuroadrenergic neurons in specific brain regions of rats. Pharmacol. Biochem. Behav. 1991 / 39 (3) / 791-793. (49) Karreman, M. et al, Effect of a pharmacological stressor on glutamate efflux in the prefrontal cortex. Brain. Res. 1996 / 716 (1-2) / 180-182. (50) Donnerer, J. ,Evidence for an excitatory action of the benzodiazepine receptor inverse agonist FG7142 on C-fibre afferents. Naunyn Schmiedebergs Arch. Pharmacol. 1989 / 340 (3) / 352-354. (51) Webb, J.K. et al, Inhibition of pentgastrin-induced pressor response in conscious rats by the CCK-8 receptor antagonist Cl-988 and chlordiazepoxide. Regul. Pept. 1996 / 61 (1) / 71-76. (52) Rodgers, R.J. et al, Benzodiazepine ligands, noiception and 'defeat' analgesia in male mice. Psychopharmacology (Berl.) 1987 / 91 (3) / 305-315. (53) Soltis, R.P. et al, Cardiovascular effects of the beta-carboline FG7142 in borderline hypertensive rats. Physiol. Behav. 1998 / 63 (3) / 407-412. , Horger, B.A. et al, Selective increase in dopamine utilization in the shell subdivision of the nucleus accumbens by the benzodiazepine inverse agonist FG7142. J. Neurochem. 1995 / 65 (2) / 770-774. , Bradberry, C.W. et al, The anxiogenic beta-carboline FG7142 selectively increases dopamine release in rat prefrontal cortex as measured by microdialysis. J. Neurochem. 1991 / 56 (2) / 748-752. , Knorr, A.M. et al, The anxiogenic beta-carboline FG7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain. Res. 1989 / 495 (2) / 355-361. , Stanford, S.C. et al, A single dose of FG7142 causes long-term increase in mouse cortical adrenoceptors. Eur. J. Pharmacol. 1987 / 134 (3) / 313-319. , Ida, Y. et al, The activation of mesoprefrontal dopamine neurons by FG7142 is absent in rats treated chronically with diazepam. Eur. J. Pharmacol. 1987 / 137 (2-3) / 185-190. , Brose, N. et al, Effects of an anxiogenic benzodiazepine receptor ligand on motor activity and dopamine release in nucleus accumbens and stratium in the rat. J. Neurosci. 1987 / 7 (9) / 2917-2926. (54) Tietz, E.I. et al, Functional GABAA receptor heterogeneity of acutely dissociated hippocampal CA1 pyramidal cells. J. Neurophysiol. 1999 / 81 (4) / 1575-1586. , Vicini, S. et al, Actions of benzodiazepine and beta-carbolin derivates on gamma-amino-butyric acid-activated Cl-channels recorded from membrane patches of neonatal rat cortical neurons in culture. J. Pharmacol. Exp. Ther. 1987 / 243 (3) / 1195-1201. , Jensen, M.S. et al, Electrophysiological studies in cultured mouse CNS neurones of the actions of an agonist and inverse agonist at the benzodiazepine receptor. Br. J. Pharmacol. 1986 / 88 (4) / 717-731. (55) Chapman, A.G. et al, Effects of two convulsant beta-carboline derivates, DMCM and beta-CCM, on regional neurotransmitter amino acid levels and on in vitro D-(3H)-aspartate release in rodents. J. Neurochem. 1985 / 45 (2) / 370-381. (56) De Boer, S.F. et al, Effects of chlordiazepoxide, flumazenil and DMCM on plasma catecholamine and corticosterone concentrations in rats. Pharmacol. Biochem. Behav. 1991 / 38 (1) / 13-19. (57) Lista, A. et al, The benzodiazepine inverse agonist DMCM decreases serotonergic transmission in rat hippocampus : an in vivo electrophysiological study. Synapse 1990 / 6 (2) / 175-180. , Lista, A. et al, Modulation of the electrically evoked release of 5-(3H)hydroxytryptamine from rat cerebral cortex : effects of alpidem, CL218,872, and diazepam. J. Neurochem. 1988 / 51 (5) / 1414-1421. (58) Yang, X.M. et al, Behavioral evidence for the role of noradrenaline in the putative anxiogenic actions of the inverse benzodiazepine receptor agonist methyl-4-6,7-dimethoxy-beta-carboline-carboxylate. J. Pharmacol. Exp. Ther. 1989 / 250 (1) / 358-363. (59) Ushijiama, I. et al, Cocaine : evidence for NMDA, beta-carboline- and dopaminergic-mediated seizures in mice. Brain. Res. 1998 / 797 (2) / 347-350. (60) Maier, S.F. et al, The dorsal raphe nucleus is a site of action mediating the behavioral effects of the benzodiazepine receptor inverse agonist DMCM. Behav. Neurosci. 1995 / 109 (4) / 759-766. , Fanselow, M.S. et al, The benzodiazepine inverse agonist DMCM as an unconditional stimulus for fear-induced analgesia : implications for the role of GABAA receptors in fear-related behaviour. Behav. Neurosci. 1992 / 106 (2) / 336-344. , Cutler, M.G. et al, Effects of the benzodiazepine receptor inverse agonist, DMCM, on the behaviour of mice : an ethopharmacological study. Neuropharmacology 1991 / 30 (12A) / 1255-1261. (61) Arora, P.K. et al, Suppression of cytotoxic T lymphocyte (CTL) activity by FG7142, a benzodiazepine receptor 'inverse agonist'. Immunopharmacology 1991 / 21 (2) / 91-97. , Petitto, J.M. et al, Suppression of natural killer cell activity by FG7142, a benzodiazepine receptor inverse agonist. Brain. Behav. Immun. 1989 / 3 (1) / 39-46. , Arora, P.K. et al, Suppression of the immune response by benzodiazepine receptor inverse agonists. J. Neuroimmunol. 1987 / 15 (1) / 1-9. Изтегляне 136.32 Kb. Сподели с приятели:
|